Skip to main content

Research Repository

See what's under the surface

Advanced Search

Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications

Ban, Lu; Tata, Laila J.; Fiaschi, Linda; Card, Timothy R.

Authors

Lu Ban

Laila J. Tata

Linda Fiaschi

Timothy R. Card



Abstract

Background & aims: Concerns persist about the risk of major congenital anomalies in children of women with inflammatory bowel disease (IBD), and whether medication use affects risk. We assessed these risks, and variations in use of medications by women with IBD before, during, and after pregnancy.

Methods: We accessed data on children born to women 15-45 y old from 1990 through 2010, using a mother-child linked dataset from an electronic database of primary care records containing medical diagnoses, events, and drug prescriptions from across the United Kingdom. We identified pregnant women with IBD, and all prescriptions for 5-aminosalicylates azathioprine/6-mercaptopurine, and corticosteroids were extracted from their primary care records. We calculated risks of major congenital anomaly in children of mothers with and without IBD, and in children exposed or not exposed to 5-aminosalicylates, azathioprine/6-mercaptopurine, or corticosteroids during their first trimester of fetal development. Logistic regression with a generalized estimating equation was used to provide risk estimates adjusted for confounders. We calculated proportions of women taking medications before, during, and after pregnancy and assessed whether cessation was associated with subsequent disease flares.

Results: Risks of a major congenital anomaly in 1703 children of mothers with IBD and 384,811 children of mothers without IBD were 2.7% and 2.8%, respectively. This corresponded to an adjusted odds ratio of 0.98 (95% confidence interval [CI], 0.73-1.31). In children of women with IBD, the adjusted odds ratios of a major congenital anomaly associated with drug use were 0.82 (95% CI, 0.42-1.61) for 5-aminosalicylates 0.48 (95% CI, 0.15-1.50) for corticosteroids, and 1.27 (95% CI, 0.48-3.39) for azathioprine/6-mercaptopurine. No increases in heart, limb, or genital anomalies were found in children of women with IBD; 31.2% of women discontinued 5-aminosalicylates and 24.6% discontinued azathioprine/6-mercaptopurine in early pregnancy. The risk of flares later in pregnancy was not related to cessation of medication.

Conclusions: We found no evidence that IBD during pregnancy or medical therapy for IBD during pregnancy increases the risk of a major congenital anomaly in children. Patients should receive appropriate guidance on use of medication before and during pregnancy.

Journal Article Type Article
Publication Date Jan 1, 2014
Journal Gastroenterology
Print ISSN 2308-2097
Electronic ISSN 1528-0012
Publisher Publishing House Zaslavsky
Peer Reviewed Peer Reviewed
Volume 146
Issue 1
APA6 Citation Ban, L., Tata, L. J., Fiaschi, L., & Card, T. R. (2014). Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications. Gastroenterology, 146(1), doi:10.1053/j.gastro.2013.09.061
DOI https://doi.org/10.1053/j.gastro.2013.09.061
Keywords Crohn's Disease; Ulcerative Colitis; Birth Defects; Treatment
Publisher URL http://www.sciencedirect.com/science/article/pii/S0016508513014376
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0
Additional Information NOTICE: this is the author’s version of a work that was accepted for publication in Gastroenterology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this
document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Gastroenterology, Vol. 146, issue 1, January 2014, pp. 76–84, doi:10.1053/j.gastro.2013.09.061

Files

Ban et al. - 2014.pdf (606 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





You might also like



Downloadable Citations

;