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The genetics of Alzheimer's disease: putting flesh on the bones

Medway, C.; Morgan, K.


C. Medway

Professor of Human Genomics and Molecular Genetics


For two decades the search for genes involved in Alzheimer's disease brought little reward; it was not until the advent of genome-wide association studies (GWAS) that genetic associations started to be revealed. Since 2009 increasingly large GWAS have revealed 20 loci, which in itself is a substantial increase in our understanding, but perhaps the more important feature is that these studies have highlighted novel pathways that are potentially involved in the disease process. This commentary assembles our latest knowledge while acknowledging that the casual functional variants, and undoubtedly, other genes are still yet to be discovered.?This is the challenge that remains and the promise of next-generation sequencing is anticipated as there are a number of large initiatives which themselves should start to yield information before long.


Medway, C., & Morgan, K. (2014). The genetics of Alzheimer's disease: putting flesh on the bones. Neuropathology and Applied Neurobiology, 40(2),

Journal Article Type Article
Publication Date Feb 1, 2014
Deposit Date Apr 1, 2014
Publicly Available Date Apr 1, 2014
Journal Neuropathology and Applied Neurobiology
Print ISSN 0305-1846
Electronic ISSN 0305-1846
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 40
Issue 2
Public URL
Publisher URL


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