Effect of ethnicity on live birth rates after in vitro fertilisation or intracytoplasmic sperm injection treatment

Jayaprakasan, K.; Pandian, D.; Hopkisson, J.; Campbell, B.K.; Maalouf, W.E.

Abstract

Objective
To assess the relationship between the ethnicity of women and the clinical success of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatment.
Design
Observational cohort study.
Setting
Nottingham University Research and Treatment Unit in Reproduction (NURTURE), UK.
Sample
A total of 1517 women, of which 1291 were white Europeans and 226 belonged to an ethnic minority group. All the women were undergoing their first cycle of assisted reproductive technology (ART) between 2006 and 2011.
Methods
All of the women underwent their first cycle of ART between 2006 and 2011.
Main outcome measures
Live birth rates following IVF or ICSI treatment.
Results
Although pre-treatment ovarian reserve variables [mean age, basal follicle stimulating hormone (FSH), and total antral follicle count] were significantly favourable in the ethnic group, the live birth rates were significantly lower in this group (35%) compared with the white European group (43.8%) (relative risk 0.8; 95% CI 0.66–0.97). On logistic regression analysis, ethnicity was an independent predictor of live birth rate (OR 0.688; 95% CI 0.513–0.924). After controlling for the other independent variables (age and FSH), the significant association between ethnicity and live birth rate remained strong (OR 0.591; 95% CI 0.425–0.822) on multivariate logistic regression analysis.
Conclusions
Live birth rates following IVF or ICSI treatment were significantly lower in the ethnic minority group compared with white European women, which suggests that ethnicity is a major determinant of live birth following IVF treatment.

Citation

Jayaprakasan, K., Pandian, D., Hopkisson, J., Campbell, B., & Maalouf, W. (2014). Effect of ethnicity on live birth rates after in vitro fertilisation or intracytoplasmic sperm injection treatment. BJOG: An International Journal of Obstetrics and Gynaecology, 121(3), https://doi.org/10.1111/1471-0528.12504

• Journal Article Type: Article
• Publication Date: Feb 1, 2014
• Deposit Date: Apr 11, 2014
• Publicly Available Date: Apr 11, 2014
• Journal: BJOG: An International Journal of Obstetrics and Gynaecology
• Print ISSN: 1470-0328
• Electronic ISSN: 1470-0328
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 121
• Issue: 3
• DOI: https://doi.org/10.1111/1471-0528.12504
• Public URL: https://nottingham-repository.worktribe.com/output/997034
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.12504/full