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DNA repair in cancer: emerging targets for personalized therapy

Abbotts, Rachel; Thompson, Nicola; Madhusudan, Srinivasan

Authors

Rachel Abbotts

Nicola Thompson



Abstract

Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity. Impaired DNA repair is a major driver for carcinogenesis and could promote aggressive cancer biology. Interestingly, in established tumors, DNA repair activity is required to counteract oxidative DNA damage that is prevalent in the tumor microenvironment. Emerging clinical data provide compelling evidence that overexpression of DNA repair factors may have prognostic and predictive significance in patients. More recently, DNA repair inhibition has emerged as a promising target for anticancer therapy. Synthetic lethality exploits intergene relationships where the loss of function of either of two related genes is nonlethal, but loss of both causes cell death. Exploiting this approach by targeting DNA repair has emerged as a promising strategy for personalized cancer therapy. In the current review, we focus on recent advances with a particular focus on synthetic lethality targeting in cancer.

Citation

Abbotts, R., Thompson, N., & Madhusudan, S. (2014). DNA repair in cancer: emerging targets for personalized therapy. Breast Cancer: Targets and Therapy, 2014(6), doi:10.2147/CMAR.S50497

Journal Article Type Article
Publication Date Feb 1, 2014
Deposit Date Apr 29, 2014
Publicly Available Date Apr 29, 2014
Journal Breast Cancer: Targets and Therapy
Electronic ISSN 1179-1314
Publisher Dove Medical Press
Peer Reviewed Peer Reviewed
Volume 2014
Issue 6
DOI https://doi.org/10.2147/CMAR.S50497
Public URL http://eprints.nottingham.ac.uk/id/eprint/3023
Publisher URL http://www.dovepress.com/dna-repair-in-cancer-emerging-targets-for-personalized-therapy-a15867

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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