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Response of Cupriavidus metallidurans CH34 to metals

Monsieurs, Pieter; Hobman, Jon L.; Vandenbussche, Guy; Mergeay, Max; Van Hoult, Rob

Authors

Pieter Monsieurs

Jon L. Hobman

Guy Vandenbussche

Max Mergeay

Rob Van Hoult



Contributors

Max Mergay
Editor

Rob Van Houdt
Editor

Abstract

Cupriavidus metallidurans CH34 displays resistance to a plethora of metals. Its response and underlying genetic determinants are dissected and detailed metal by metal (from arsenic to zinc). An important role for its megaplasmids pMOL28 and pMOL30 is shown, with high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification often accompanied by other functions linked to acute or chronic stress. Nevertheless, metal resistance determinants are also found on the chromid (e.g. to chromate, copper and zinc) as well as on a large genomic island integrated in the chromosome (e.g. to cadmium, lead and mercury), even the core genome participates in certain responses such as to gold or selenium. Next, we summarized the environmental applications, which were developed based on the knowledge gained by studying these different determinants, and in particular biosensors and soil and water bioremediation. Finally, the general transcriptional response of C. metallidurans to sixteen different metals supplied at different concentrations (including acute stress) is discussed within the framework of its intricate regulatory network.

Publication Date Jan 1, 2015
Peer Reviewed Peer Reviewed
Volume 1
Series Title SpringerBriefs in biometals
Book Title Metal response in Cupriavidus metallidurans Volume 1: From habitats to genes and proteins
ISBN 978331920593-9
APA6 Citation Monsieurs, P., Hobman, J. L., Vandenbussche, G., Mergeay, M., & Van Hoult, R. (2015). Response of Cupriavidus metallidurans CH34 to metals. In M. Mergay, & R. Van Houdt (Eds.), Metal response in Cupriavidus metallidurans Volume 1: From habitats to genes and proteinsSpringer. doi:10.1007/978-3-319-20594-6
DOI https://doi.org/10.1007/978-3-319-20594-6
Keywords Applied microbiology, Microbiology, Biogeosciences, Environmental engineering, Biotechnology
Publisher URL http://www.springer.com/gb/book/9783319205939
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
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