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Temperature-ramped 129Xe spin-exchange optical pumping

Nikolaou, Panayiotis; Coffey, Aaron M.; Barlow, Michael J.; Rosen, Matthew S.; Goodson, Boyd M.; Chekmenev, Eduard Y.

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Authors

Panayiotis Nikolaou

Aaron M. Coffey

Michael J. Barlow

Matthew S. Rosen

Boyd M. Goodson

Eduard Y. Chekmenev



Abstract

We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode 129Xe hyperpolarizer utilizing three key temperature regimes: (i) “hot”—where the 129Xe hyperpolarization rate is maximal, (ii) “warm”—where the 129Xe hyperpolarization approaches unity, and (iii) “cool”—where hyperpolarized 129Xe gas is transferred into a Tedlar bag with low Rb content ([less than] 5 ng per ~ 1 L dose) suitable for human imaging applications. Unlike with the conventional approach of batch-mode SEOP, here all three temperature regimes may be operated under continuous high-power (170 W) laser irradiation, and hyperpolarized 129Xe gas is delivered without the need for a cryocollection step. The variable-temperature approach increased the SEOP rate by more than 2-fold compared to the constant-temperature polarization rate (e.g., giving effective values for the exponential buildup constant γSEOP of 62.5 ± 3.7 × 10–3 min–1 vs 29.9 ± 1.2 × 10–3 min–1) while achieving nearly the same maximum %PXe value (88.0 ± 0.8% vs 90.1% ± 0.8%, for a 500 Torr (67 kPa) Xe cell loading—corresponding to nuclear magnetic resonance/magnetic resonance imaging (NMR/MRI) enhancements of ∼3.1 × 105 and ∼2.32 × 108 at the relevant fields for clinical imaging and HP 129Xe production of 3 T and 4 mT, respectively); moreover, the intercycle “dead” time was also significantly decreased. The higher-throughput TR-SEOP approach can be implemented without sacrificing the level of 129Xe hyperpolarization or the experimental stability for automation—making this approach beneficial for improving the overall 129Xe production rate in clinical settings.

Citation

Nikolaou, P., Coffey, A. M., Barlow, M. J., Rosen, M. S., Goodson, B. M., & Chekmenev, E. Y. (2014). Temperature-ramped 129Xe spin-exchange optical pumping. Analytical Chemistry, 86(16), 8206-8212. https://doi.org/10.1021/ac501537w

Journal Article Type Article
Acceptance Date Jun 26, 2014
Online Publication Date Jul 10, 2014
Publication Date Aug 19, 2014
Deposit Date Aug 9, 2018
Publicly Available Date Aug 9, 2018
Journal Analytical Chemistry
Print ISSN 0003-2700
Electronic ISSN 1520-6882
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 86
Issue 16
Pages 8206-8212
DOI https://doi.org/10.1021/ac501537w
Public URL https://nottingham-repository.worktribe.com/output/986798
Publisher URL https://pubs.acs.org/doi/10.1021/ac501537w
Contract Date Aug 9, 2018

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