Temperature-ramped 129Xe spin-exchange optical pumping

Nikolaou, Panayiotis; Coffey, Aaron M.; Barlow, Michael J.; Rosen, Matthew S.; Goodson, Boyd M.; Chekmenev, Eduard Y.

Abstract

We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode 129Xe hyperpolarizer utilizing three key temperature regimes: (i) “hot”—where the 129Xe hyperpolarization rate is maximal, (ii) “warm”—where the 129Xe hyperpolarization approaches unity, and (iii) “cool”—where hyperpolarized 129Xe gas is transferred into a Tedlar bag with low Rb content ([less than] 5 ng per ~ 1 L dose) suitable for human imaging applications. Unlike with the conventional approach of batch-mode SEOP, here all three temperature regimes may be operated under continuous high-power (170 W) laser irradiation, and hyperpolarized 129Xe gas is delivered without the need for a cryocollection step. The variable-temperature approach increased the SEOP rate by more than 2-fold compared to the constant-temperature polarization rate (e.g., giving effective values for the exponential buildup constant γSEOP of 62.5 ± 3.7 × 10–3 min–1 vs 29.9 ± 1.2 × 10–3 min–1) while achieving nearly the same maximum %PXe value (88.0 ± 0.8% vs 90.1% ± 0.8%, for a 500 Torr (67 kPa) Xe cell loading—corresponding to nuclear magnetic resonance/magnetic resonance imaging (NMR/MRI) enhancements of ∼3.1 × 105 and ∼2.32 × 108 at the relevant fields for clinical imaging and HP 129Xe production of 3 T and 4 mT, respectively); moreover, the intercycle “dead” time was also significantly decreased. The higher-throughput TR-SEOP approach can be implemented without sacrificing the level of 129Xe hyperpolarization or the experimental stability for automation—making this approach beneficial for improving the overall 129Xe production rate in clinical settings.

Citation

Nikolaou, P., Coffey, A. M., Barlow, M. J., Rosen, M. S., Goodson, B. M., & Chekmenev, E. Y. (2014). Temperature-ramped 129Xe spin-exchange optical pumping. Analytical Chemistry, 86(16), 8206-8212. https://doi.org/10.1021/ac501537w

• Journal Article Type: Article
• Acceptance Date: Jun 26, 2014
• Online Publication Date: Jul 10, 2014
• Publication Date: Aug 19, 2014
• Deposit Date: Aug 9, 2018
• Publicly Available Date: Aug 9, 2018
• Journal: Analytical Chemistry
• Print ISSN: 0003-2700
• Electronic ISSN: 1520-6882
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 86
• Issue: 16
• Pages: 8206-8212
• DOI: https://doi.org/10.1021/ac501537w
• Public URL: https://nottingham-repository.worktribe.com/output/986798
• Publisher URL: https://pubs.acs.org/doi/10.1021/ac501537w