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Mathematical modelling of hepatic lipid metabolism

Pratt, Adrian C.; Wattis, Jonathan A.D.; Salter, Andrew M.

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Adrian C. Pratt

Professor of Applied Mathematics

Andrew M. Salter


The aim of this paper is to develop a mathematical model capable of simulating the metabolic response to a variety of mixed meals in fed and fasted conditions with particular emphasis placed on the hepatic triglyceride element of the model. Model validation is carried out using experimental data for the ingestion of three mixed composition meals over a 24-hour period. Comparison with experimental data suggests the model predicts key plasma lipids accurately given a prescribed insulin profile. One counter-intuitive observation to arise from simulations is that liver triglyceride initially decreases when a high fat meal is ingested, a phenomenon potentially explained by the carbohydrate portion of the meal raising plasma insulin.

Journal Article Type Article
Publication Date Apr 1, 2015
Deposit Date Jul 3, 2015
Publicly Available Date Jul 3, 2015
Journal Mathematical Biosciences
Print ISSN 0025-5564
Electronic ISSN 0025-5564
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 262
Public URL
Publisher URL


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