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Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC)

Olarte-Sánchez, Cristian; Valencia-Torres, L.; Cassaday, Helen J.; Bradshaw, Chris; Szabadi, Elemer

Authors

Cristian Olarte-Sánchez

L. Valencia-Torres

Helen J. Cassaday

Chris Bradshaw

Elemer Szabadi



Abstract

Rats’ performance on a progressive-ratio schedule maintained by sucrose (0.6 M, 50 μl) and corn oil (100%, 25 μl) reinforcers was assessed using a model derived from Killeen’s (1994) theory of scheduled-controlled behaviour, ‘Mathematical Principles of Reinforcement’. When the rats were maintained at 80% of their free-feeding body weights, the parameter expressing incentive value, a, was greater for the corn oil than for the sucrose reinforcer; the response-time parameter, δ, did not differ between the reinforcer types, but a parameter derived from the linear waiting principle (Tₒ), indicated that the minimum post-reinforcement pause was longer for corn oil than for sucrose. When the rats were maintained under free-feeding conditions, a was reduced, indicating a reduction of incentive value, but δ was unaltered. Under the food-deprived condition, the CB1 cannabinoid receptor agonist Δ⁹-tetrahydrocannabinol (THC: 0.3, 1 and 3 mg kg-1) increased the value of sucrose; none of the other parameters was affected by THC. The results provide new information about the sensitivity of the model’s parameters to deprivation and reinforcer quality, and suggest that THC selectively enhances the incentive value of sucrose.

Citation

Olarte-Sánchez, C., Valencia-Torres, L., Cassaday, H. J., Bradshaw, C., & Szabadi, E. (2015). Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC). Behavioural Processes, 113, https://doi.org/10.1016/j.beproc.2015.01.014

Journal Article Type Article
Publication Date Apr 1, 2015
Deposit Date Feb 26, 2015
Publicly Available Date Apr 1, 2015
Journal Behavioural Processes
Print ISSN 0376-6357
Electronic ISSN 0376-6357
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 113
DOI https://doi.org/10.1016/j.beproc.2015.01.014
Keywords Progressive-Ratio Schedule, Mathematical Principles of Reinforcement, Mathematical Model, Food Deprivation, Sucrose, Corn Oil, Δ9-Tetrahydrocannabinol, Incentive Value, Rat
Public URL http://eprints.nottingham.ac.uk/id/eprint/28311
Publisher URL http://www.sciencedirect.com/science/article/pii/S037663571500042X
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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