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Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island"

Hao, Xiuli; Luthje, Freja L.; Qin, Yanan; McDevitt, Sylvia Franke; Lutay, Nataliya; Hobman, John L.; Asiani, Karishma; Soncini, Fernando C.; German, Nadezhda; Zhang, Siyu; Zhu, Yong-Guan; Rensing, Christopher

Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" Thumbnail


Authors

Xiuli Hao

Freja L. Luthje

Yanan Qin

Sylvia Franke McDevitt

Nataliya Lutay

JON HOBMAN jon.hobman@nottingham.ac.uk
Associate Professor

Karishma Asiani

Fernando C. Soncini

Nadezhda German

Siyu Zhang

Yong-Guan Zhu

Christopher Rensing



Abstract

The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. While this is certainly true, we hypothesize that protozoan predation and macrophage killing are also responsible for selection of copper/zinc resistance genes in bacteria. In this review, we outline evidence supporting this hypothesis, as well as highlight the correlation between metal resistance and pathogenicity in bacteria. In addition, we introduce and characterize the "copper pathogenicity island" identified in Escherichia coli and Salmonella strains isolated from copper- and zinc-fed Danish pigs.

Journal Article Type Article
Publication Date Jul 1, 2015
Deposit Date Feb 11, 2016
Publicly Available Date Feb 11, 2016
Journal Applied Microbiology and Biotechnology
Print ISSN 0175-7598
Electronic ISSN 1432-0614
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 99
Issue 14
DOI https://doi.org/10.1007/s00253-015-6749-0
Keywords Copper, Pathogenicity, Amoeba, Grazing resistance
Public URL https://nottingham-repository.worktribe.com/output/982992
Publisher URL http://link.springer.com/article/10.1007/s00253-015-6749-0
Additional Information The final publication is available at Springer via http://dx.doi.org/10.1007/s00253-015-6749-0

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