JOANNE MORLING JOANNE.MORLING@NOTTINGHAM.AC.UK
Clinical Associate Professor
Clinically significant chronic liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
Morling, Joanne R.; Fallowfield, Jonathan A.; Guha, Indra N.; Williamson, Rachel M.; Glancy, Stephen; Strachan, Mark W.J.; Price, Jackie F.
Authors
Jonathan A. Fallowfield
Indra N. Guha
Rachel M. Williamson
Stephen Glancy
Mark W.J. Strachan
Jackie F. Price
Abstract
Background: Type 2 diabetes is an independent risk factor for chronic liver disease, however disease burden estimates and knowledge of prognostic indicators are lacking in community populations.
Aims: To describe the prevalence and incidence of clinically significant chronic liver disease amongst community-based older people with Type 2 diabetes and to determine risk factors which might assist in discriminating patients with unknown prevalent or incident disease.
Design: Prospective cohort study.
Methods: Nine hundred and thirty-nine participants in the Edinburgh Type 2 Diabetes Study underwent investigation including liver ultrasound and non-invasive measures of non-alcoholic steatohepatitis (NASH), hepatic fibrosis and systemic inflammation. Over 6-years, cases of cirrhosis and hepatocellular carcinoma were collated from multiple sources.
Results: Eight patients had known prevalent disease with 13 further unknown cases identified (prevalence 2.2%) and 15 incident cases (IR 2.9/1000 person-years). Higher levels of systemic inflammation, NASH and hepatic fibrosis markers were associated with both unknown prevalent and incident clinically significant chronic liver disease (all P?
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 5, 2015 |
Online Publication Date | Oct 9, 2015 |
Publication Date | Apr 1, 2016 |
Deposit Date | Mar 2, 2016 |
Publicly Available Date | Mar 2, 2016 |
Journal | QJM: An International Journal of Medicine |
Print ISSN | 1460-2725 |
Electronic ISSN | 1460-2725 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 109 |
Issue | 4 |
DOI | https://doi.org/10.1093/qjmed/hcv191 |
Public URL | https://nottingham-repository.worktribe.com/output/977438 |
Publisher URL | http://qjmed.oxfordjournals.org/content/early/2015/11/05/qjmed.hcv191 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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