Clinically significant chronic liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

Morling, Joanne R.; Fallowfield, Jonathan A.; Guha, Indra N.; Williamson, Rachel M.; Glancy, Stephen; Strachan, Mark W.J.; Price, Jackie F.

Abstract

Background: Type 2 diabetes is an independent risk factor for chronic liver disease, however disease burden estimates and knowledge of prognostic indicators are lacking in community populations.

Aims: To describe the prevalence and incidence of clinically significant chronic liver disease amongst community-based older people with Type 2 diabetes and to determine risk factors which might assist in discriminating patients with unknown prevalent or incident disease.

Design: Prospective cohort study.

Methods: Nine hundred and thirty-nine participants in the Edinburgh Type 2 Diabetes Study underwent investigation including liver ultrasound and non-invasive measures of non-alcoholic steatohepatitis (NASH), hepatic fibrosis and systemic inflammation. Over 6-years, cases of cirrhosis and hepatocellular carcinoma were collated from multiple sources.

Results: Eight patients had known prevalent disease with 13 further unknown cases identified (prevalence 2.2%) and 15 incident cases (IR 2.9/1000 person-years). Higher levels of systemic inflammation, NASH and hepatic fibrosis markers were associated with both unknown prevalent and incident clinically significant chronic liver disease (all P?

Citation

Morling, J. R., Fallowfield, J. A., Guha, I. N., Williamson, R. M., Glancy, S., Strachan, M. W., & Price, J. F. (2016). Clinically significant chronic liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. QJM: An International Journal of Medicine, 109(4), https://doi.org/10.1093/qjmed/hcv191

• Journal Article Type: Article
• Acceptance Date: Oct 5, 2015
• Online Publication Date: Oct 9, 2015
• Publication Date: Apr 1, 2016
• Deposit Date: Mar 2, 2016
• Publicly Available Date: Mar 2, 2016
• Journal: QJM: An International Journal of Medicine
• Print ISSN: 1460-2725
• Electronic ISSN: 1460-2725
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 109
• Issue: 4
• DOI: https://doi.org/10.1093/qjmed/hcv191
• Public URL: https://nottingham-repository.worktribe.com/output/977438
• Publisher URL: http://qjmed.oxfordjournals.org/content/early/2015/11/05/qjmed.hcv191