Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?
Aldiss, Peter; Budge, Helen; Symonds, Michael E.
HELEN BUDGE HELEN.BUDGE@NOTTINGHAM.AC.UK
Professor of Neonatal Medicine
Michael E. Symonds
Maintenance of thermal homeostasis within a tight range is regulated not only by a variety of internal and external cues but also by sex and biological age. The major organ responsible for adaptive thermogenesis is brown adipose tissue (BAT) and the recent re-discovery of its presence in adult humans has led to huge interest in the role that it may play in modulating cardiometabolic health. Interestingly, as with maintenance of thermal homeostasis, the total amount and metabolic activity of BAT is modulated by sex and biological age. In this short commentary we discuss the recent finding that core-body temperature is reduced in women post-menopause, a period when excess adiposity and increased risk of cardiometabolic disease is evident and postulate that alterations in sex hormones downregulated the thermogenic activity of BAT cold contribute to this deleterious phenotype.
Aldiss, P., Budge, H., & Symonds, M. E. (2016). Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?. Cardiovascular Endocrinology, 5(4), https://doi.org/10.1097/XCE.0000000000000089
|Journal Article Type||Article|
|Acceptance Date||Jun 24, 2016|
|Publication Date||Dec 1, 2016|
|Deposit Date||Nov 22, 2016|
|Publicly Available Date||Dec 1, 2016|
|Publisher||Lippincott, Williams & Wilkins|
|Peer Reviewed||Peer Reviewed|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf|
|Additional Information||This is a non-final version of an article published in final form in Cardiovascular Endocrinology December 2016. Volume 5. Issue 4, p. 155–156
Aldiss et al Commentary May 2016 Final.pdf
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
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