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Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?

Aldiss, Peter; Budge, Helen; Symonds, Michael E.

Authors

Peter Aldiss

HELEN BUDGE HELEN.BUDGE@NOTTINGHAM.AC.UK
Professor of Neonatal Medicine

Michael E. Symonds



Abstract

Maintenance of thermal homeostasis within a tight range is regulated not only by a variety of internal and external cues but also by sex and biological age. The major organ responsible for adaptive thermogenesis is brown adipose tissue (BAT) and the recent re-discovery of its presence in adult humans has led to huge interest in the role that it may play in modulating cardiometabolic health. Interestingly, as with maintenance of thermal homeostasis, the total amount and metabolic activity of BAT is modulated by sex and biological age. In this short commentary we discuss the recent finding that core-body temperature is reduced in women post-menopause, a period when excess adiposity and increased risk of cardiometabolic disease is evident and postulate that alterations in sex hormones downregulated the thermogenic activity of BAT cold contribute to this deleterious phenotype.

Citation

Aldiss, P., Budge, H., & Symonds, M. E. (2016). Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?. Cardiovascular Endocrinology, 5(4), https://doi.org/10.1097/XCE.0000000000000089

Journal Article Type Article
Acceptance Date Jun 24, 2016
Publication Date Dec 1, 2016
Deposit Date Nov 22, 2016
Publicly Available Date Dec 1, 2016
Journal Cardiovascular Endocrinology
Print ISSN 2162-688X
Electronic ISSN 2162-688X
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 5
Issue 4
DOI https://doi.org/10.1097/XCE.0000000000000089
Public URL http://eprints.nottingham.ac.uk/id/eprint/38887
Publisher URL https://doi.org/10.1097/XCE.0000000000000089
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information This is a non-final version of an article published in final form in Cardiovascular Endocrinology December 2016. Volume 5. Issue 4, p. 155–156
available at
https://doi.org/10.1097/XCE.0000000000000089

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Aldiss et al Commentary May 2016 Final.pdf (345 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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