Is clarithromycin a potential treatment for cachexia in people with lung cancer?: a feasibility study

Awan, Sarah; Crosby, Vincent; Potter, Vanessa; Hennig, Ivo; Baldwin, David; Ndlovu, Mehluli; Paradine, Sharon; Wilcock, Andrew

Abstract

Clarithromycin may improve cachexia and survival in non-small cell lung cancer (NSCLC), but adequately controlled data are lacking. This study was undertaken primarily to inform the feasibility and scale of a phase III trial. Eligible consenting patients with stage IV NSCLC and cachexia were to be randomized to receive either clarithromycin 250 mg twice daily or placebo for eight weeks. Aspects of trial feasibility recorded included numbers eligible, approached and recruited, together with adherence and completion of treatment and assessments. Over 6 months, none of 125 patients identified fulfilled the entry criteria. The commonest reasons for ineligibility were the use of an excluded concurrent drug (45, 36%), brain metastases (22, 18%), poor performance status (21, 17%) and current chemotherapy (15, 12%). A phase III trial of clarithromycin using these entry criteria is not feasible in this setting. Other macrolides that have a lower risk of a drug–drug interaction may be more practical to pursue.

Citation

Awan, S., Crosby, V., Potter, V., Hennig, I., Baldwin, D., Ndlovu, M., …Wilcock, A. (2017). Is clarithromycin a potential treatment for cachexia in people with lung cancer?: a feasibility study. Lung Cancer, 104, https://doi.org/10.1016/j.lungcan.2016.12.010

• Journal Article Type: Article
• Acceptance Date: Dec 18, 2016
• Online Publication Date: Dec 21, 2016
• Publication Date: Feb 1, 2017
• Deposit Date: Nov 20, 2017
• Publicly Available Date: Nov 20, 2017
• Journal: Lung Cancer
• Print ISSN: 0169-5002
• Electronic ISSN: 0169-5002
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 104
• DOI: https://doi.org/10.1016/j.lungcan.2016.12.010
• Keywords: Cachexia; Clarithromycin; Macrolide antibiotics; Non-small cell lung cancer
• Public URL: https://nottingham-repository.worktribe.com/output/970565
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0169500216305773