Neohormones in milk

Ivell, Richard; Anand-Ivell, Ravinder

Abstract

Neohormone systems evolved specifically to regulate those mammalian traits, such as internal fertilization, pregnancy and lactation, which have proved to be central to the success, environmental independence, and adaptability of mammals as a vertebrate group. Neohormones such as oxytocin or relaxin are not only involved in the regulation of mammary gland development and function, but are also significant components of milk itself. Particularly for the latter hormone, it has been shown for the pig that relaxin in the first milk is taken up by the gastrointestinal tract of the offspring, enters the neonatal circulation and can have specific physiological and epigenetic effects on target organs such as the female reproductive system. Nevertheless, there are large gaps in our knowledge and understanding of such lactocrine systems especially in regard to other neohormones, species, and neonatal organ systems.

Citation

Ivell, R., & Anand-Ivell, R. (2017). Neohormones in milk. Best Practice and Research: Clinical Endocrinology and Metabolism, 31(4), https://doi.org/10.1016/j.beem.2017.10.005

• Journal Article Type: Article
• Acceptance Date: Oct 12, 2017
• Online Publication Date: Oct 27, 2017
• Publication Date: Oct 27, 2017
• Deposit Date: Oct 23, 2017
• Publicly Available Date: Oct 27, 2017
• Journal: Best Practice & Research Clinical Endocrinology & Metabolism
• Electronic ISSN: 1878-1594
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 31
• Issue: 4
• DOI: https://doi.org/10.1016/j.beem.2017.10.005
• Keywords: Neohormone, Oxytocin, Relaxin, Insulin-like peptide 3, INSL3, Human Chorionic Gonadotrophin, Mammary gland, Lactation, Milk, Lactocrine
• Public URL: https://nottingham-repository.worktribe.com/output/967329
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1521690X17301033