Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study

Ma, Christopher; Moran, Gordon W.; Benchimol, Eric I.; Targownik, Laura E.; Heitman, Steven J.; Hubbard, James N.; Seow, Cynthia H.; Novak, Kerri L.; Ghosh, Subrata; Panaccione, Remo; Kaplan, Gilaad G.

Abstract

Objectives:
Temporal changes for intestinal resections for Crohn’s disease (CD) are controversial. We validated administrative database codes for CD diagnosis and surgery in hospitalized patients and then evaluated temporal trends in CD surgical resection rates.
Methods:
First, we validated International Classification of Disease (ICD)-10-CM coding for CD diagnosis in hospitalized patients and Canadian Classification of Health Intervention coding for surgical resections. Second, we used these validated codes to conduct population-based surveillance between fiscal years 2002 and 2010 to identify adult CD patients undergoing intestinal resection (n=981). Annual surgical rate was calculated by dividing incident surgeries by estimated CD prevalence. Time trend analysis was performed and annual percent change (APC) with 95% confidence intervals (CI) in surgical resection rates were calculated using a generalized linear model assuming a Poisson distribution.
Results:
In the validation cohort, 101/104 (97.1%) patients undergoing surgery and 191/200 (95.5%) patients admitted without surgery were confirmed to have CD on chart review. Among the 116 administrative database codes for surgical resection, 97.4% were confirmed intestinal resections on chart review. From 2002 to 2010, the overall CD surgical resection rate was 3.8 resections per 100 person-years. During the study period, rate of surgery decreased by 3.5% per year (95% CI: -1.1%, -5.8%), driven by decreasing emergent operations (-10.1% per year [95% CI: -13.4%, -6.7%]) whereas elective surgeries increased by 3.7% per year (95% CI: 0.1%, 7.3%).
Conclusions:
Overall surgical resection rates in CD are decreasing, but a paradigm shift has occurred whereby elective operations are now more commonly performed than emergent surgeries.

Citation

Ma, C., Moran, G. W., Benchimol, E. I., Targownik, L. E., Heitman, S. J., Hubbard, J. N., …Kaplan, G. G. (2017). Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study. American Journal of Gastroenterology, 112, https://doi.org/10.1038/ajg.2017.394

• Journal Article Type: Article
• Acceptance Date: Aug 10, 2017
• Online Publication Date: Oct 31, 2017
• Publication Date: Dec 1, 2017
• Deposit Date: Nov 1, 2017
• Publicly Available Date: Nov 1, 2017
• Journal: American Journal of Gastroenterology
• Print ISSN: 0002-9270
• Electronic ISSN: 1572-0241
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 112
• DOI: https://doi.org/10.1038/ajg.2017.394
• Keywords: Crohn’s disease; surgery; ICD-10-CM; validation
• Public URL: https://nottingham-repository.worktribe.com/output/964751
• Publisher URL: https://www.nature.com/ajg/journal/vaop/ncurrent/full/ajg2017394a.html