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Transaminases for chiral amine synthesis

Gomm, Andrew; O'Reilly, Elaine

Authors

Andrew Gomm

Elaine O'Reilly



Abstract

Amine transaminases are important biocatalysts for the synthesis of chiral primary amines. Unlike many enzymes that have been employed for the synthesis of optically active amines, amine transaminases are capable of asymmetric synthesis and do not rely on costly cofactors that must be regenerated in situ. However, their application as general catalysts for the preparation of amines is hampered by a limited substrate scope, substrate and (co)product inhibition and difficulties associated with displacing challenging reaction equilibrium. There has been important progress made to overcome these challenges, including the development of enzymes with broader substrate scope and the design of methodology to effectively displace the reaction equilibrium. Amine transaminases are also being applied in an increasing range of (chemo)enzymatic cascades and immobilized for applications in flow.

Citation

Gomm, A., & O'Reilly, E. (2018). Transaminases for chiral amine synthesis. Current Opinion in Chemical Biology, 43, https://doi.org/10.1016/j.cbpa.2017.12.007

Journal Article Type Article
Acceptance Date Dec 12, 2017
Online Publication Date Jan 4, 2018
Publication Date Apr 1, 2018
Deposit Date Jan 12, 2018
Publicly Available Date Jan 5, 2019
Journal Current Opinion in Chemical Biology
Print ISSN 1367-5931
Electronic ISSN 1879-0402
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 43
DOI https://doi.org/10.1016/j.cbpa.2017.12.007
Public URL http://eprints.nottingham.ac.uk/id/eprint/49054
Publisher URL https://www.sciencedirect.com/science/article/pii/S1367593117301734
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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