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Gainfully employing descending controls in acute and chronic pain management

White, Kate; Targett, Mike; Harris, John

Authors

KATE WHITE KATE.WHITE@NOTTINGHAM.AC.UK
Professor of Veterinary Anaesthesia and Analgesia

MIKE TARGETT mike.targett@nottingham.ac.uk
Clinical Associate Professor



Abstract

Specific primary afferent fibres termed nociceptors are responsible for transmitting nociceptive information. Centrally the axonal terminals of these fibres synapse with secondary projection neurones in the spinal dorsal horn to transmit nociceptive information to the higher centres in the brain. Irrespective of the presence or absence of nociceptive inflow the activity of dorsal horn neurones is modulated by, amongst other things, local interneurones and descending midbrain and brainstem networks which can inhibit or facilitate dorsal horn transmission. These pathways therefore set the threshold for information inflow to the CNS. This review article summarises the anatomy, physiology and pharmacology particularly of these descending inhibitory and facilitatory pathways and explains why the study of descending modulation is essential if we are to develop more efficacious interventions for treating pain and relieving suffering.

Citation

White, K., Targett, M., & Harris, J. (2018). Gainfully employing descending controls in acute and chronic pain management. Veterinary Journal, 237, https://doi.org/10.1016/j.tvjl.2018.05.005

Journal Article Type Article
Acceptance Date May 19, 2018
Online Publication Date May 19, 2018
Publication Date Jul 30, 2018
Deposit Date May 23, 2018
Publicly Available Date May 20, 2019
Journal Veterinary Journal
Electronic ISSN 1532-2971
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 237
DOI https://doi.org/10.1016/j.tvjl.2018.05.005
Keywords Analgesia; DNIC; Nociception; Pain modulation
Public URL http://eprints.nottingham.ac.uk/id/eprint/51987
Publisher URL https://www.sciencedirect.com/science/article/pii/S1090023318301801
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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1-s2.0-S1090023318301801-main White.pdf (543 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0


1-s2.0-S1090023318301801-main White.pdf (656 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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