Skip to main content

Research Repository

Advanced Search

Endocrine therapy for breast cancer: a model of hormonal manipulation

Johnston, Simon J.; Cheung, Kwok-Leung


Professor of Respiratory Medicine


Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited in combination with established endocrine therapies to maximise efficacy. However, clinicians must balance this gain against the risk to patients of increased side effects with combination therapies. This article provides a succinct outline of the principles of hormonal manipulation in breast cancer, alongside the key evidence that underpins current clinical practice. As the role of endocrine therapy in breast cancer continues to expand, the challenge is to interpret the data and select the optimal strategy for a given clinical scenario.


Johnston, S. J., & Cheung, K. (in press). Endocrine therapy for breast cancer: a model of hormonal manipulation. Oncology and Therapy,

Journal Article Type Article
Acceptance Date Jun 21, 2018
Online Publication Date Jul 10, 2018
Deposit Date Jul 17, 2018
Publicly Available Date Jul 17, 2018
Journal Oncology and Therapy
Electronic ISSN 2366-1089
Peer Reviewed Peer Reviewed
Keywords Breast cancer; Combination therapy; Endocrine therapy; Hormone; Oestrogen receptor; Targeted therapy
Public URL
Publisher URL


You might also like

Downloadable Citations