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MDM2 expression in the progression of Barrett’s oesophagus

Robinson, Leora; Ilyas, Mohammad; Ragunath, Krish; Card, Timothy R.; Abradu-Berchie, Berice; Kaye, Philip

Authors

Leora Robinson

Krish Ragunath K.Ragunath@nottingham.ac.uk

Dr TIM CARD tim.card@nottingham.ac.uk
Clinical Associate Professor

Berice Abradu-Berchie

Philip Kaye Philip.kaye@nuh.nhs.uk



Abstract

Barrett's oesophagus (BO) is the main precursor for oesophageal adenocarcinoma (OAC), and dysplasia arising within it is the standard marker used to predict risk of malignant progression. However, dysplasia diagnosis is subject to a significant amount of interobserver variation. Biomarkers may aid the diagnosis of dysplasia and may help predict the risk of progression to OAC. Abnormal expression of p53 can be reproducibly detected by immunohistochemistry (IHC) and it is an effective marker of risk of OAC1. There is however still a need for additional early stage markers.

Journal Article Type Article
Publication Date Jun 30, 2018
Journal Histopathology
Print ISSN 0309-0167
Electronic ISSN 1365-2559
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 72
Issue 7
APA6 Citation Robinson, L., Ilyas, M., Ragunath, K., Card, T. R., Abradu-Berchie, B., & Kaye, P. (2018). MDM2 expression in the progression of Barrett’s oesophagus. Histopathology, 72(7), https://doi.org/10.1111/his.13480
DOI https://doi.org/10.1111/his.13480
Keywords Barret’s oesophagus; MDM2; p53; Dysplasia
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/his.13480/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article: Robinson, L., Ilyas, M., Ragunath, K., Card, T., Abradu-Berchie, B. and Kaye, P. (), MDM2 Expression in the Progression of Barrett's Oesophagus. Histopathology. Accepted Author Manuscript. doi:10.1111/his.13480
, which has been published in final form at http://onlinelibrary.wi...111/his.13480/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Updated - MDM2 Expression in the Progression of Barrett final PVK histopathology update jan 2018 leora edit.pdf (449 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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