MDM2 expression in the progression of Barrett’s oesophagus

Robinson, Leora; Ilyas, Mohammad; Ragunath, Krish; Card, Timothy R.; Abradu-Berchie, Berice; Kaye, Philip

Abstract

Barrett's oesophagus (BO) is the main precursor for oesophageal adenocarcinoma (OAC), and dysplasia arising within it is the standard marker used to predict risk of malignant progression. However, dysplasia diagnosis is subject to a significant amount of interobserver variation. Biomarkers may aid the diagnosis of dysplasia and may help predict the risk of progression to OAC. Abnormal expression of p53 can be reproducibly detected by immunohistochemistry (IHC) and it is an effective marker of risk of OAC1. There is however still a need for additional early stage markers.

Citation

Robinson, L., Ilyas, M., Ragunath, K., Card, T. R., Abradu-Berchie, B., & Kaye, P. (2018). MDM2 expression in the progression of Barrett’s oesophagus. Histopathology, 72(7), 1230-1233. https://doi.org/10.1111/his.13480

• Journal Article Type: Article
• Acceptance Date: Feb 2, 2018
• Online Publication Date: Feb 10, 2018
• Publication Date: Jun 30, 2018
• Deposit Date: Feb 7, 2018
• Publicly Available Date: Feb 11, 2019
• Journal: Histopathology
• Print ISSN: 0309-0167
• Electronic ISSN: 1365-2559
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 72
• Issue: 7
• Pages: 1230-1233
• DOI: https://doi.org/10.1111/his.13480
• Keywords: Barret’s oesophagus; MDM2; p53; Dysplasia
• Public URL: https://nottingham-repository.worktribe.com/output/944214
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1111/his.13480/abstract
• Additional Information: This is the peer reviewed version of the following article: Robinson, L., Ilyas, M., Ragunath, K., Card, T., Abradu-Berchie, B. and Kaye, P. (), MDM2 Expression in the Progression of Barrett's Oesophagus. Histopathology. Accepted Author Manuscript. doi:10.1111/his.13480; , which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/his.13480/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.