Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity

Mondal, Satyajit; Chakraborty, Moumita; Mondal, Antu; Pakhira, Bholanath; Blake, Alexander J.; Sinn, Ekkehard; Chattopadhyay, Shyamal Kumar

Abstract

Two new Cu(II) complexes [Cu(L1)(N3)](1) and [Cu(L1)(NCS)]n(2), where HL1 ((E)-4-((2(dimethylamino)ethylimino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol) is a N,N,O-donor Schiff base ligand, have been synthesized. These complexes were characterized on the basis of spectroscopic, electrochemical, and other physicochemical properties. X-ray crystal structure determination reveals that in complex 1, Cu(II) is in a square planar geometry with the N,N,O-donor ligand and a terminally coordinated azide ion. In complex 2, however, Cu(II) assumes a square pyramidal geometry, and apart from the tridentate Schiff base ligand there is a thiocyanate ion, which acts in a μ1,3-bridging mode, connecting adjacent Cu(II) atoms in an axial-equatorial fashion forming an one dimensional chain. Cyclic voltammetry shows that complexes undergo Cu(II)/Cu(I) reductions at −0.40 to −0.55V followed by imine reduction at around −0.7V. Cu(I)/Cu(0) reduction is observed at approximately −0.9V. Complex 1 also shows appreciable catalytic activity for the aerial oxidation of 3,5 DTBCH2 to DTBQ (catecholase activity). Both the complexes also show strong binding affinity towards calf-thymus DNA.

Citation

Mondal, S., Chakraborty, M., Mondal, A., Pakhira, B., Blake, A. J., Sinn, E., & Chattopadhyay, S. K. (2018). Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity. New Journal of Chemistry, 42(12), https://doi.org/10.1039/C8NJ00418H

• Journal Article Type: Article
• Acceptance Date: Apr 16, 2018
• Online Publication Date: Apr 18, 2018
• Publication Date: Jun 21, 2018
• Deposit Date: Jul 5, 2018
• Publicly Available Date: Apr 19, 2019
• Journal: New Journal of Chemistry
• Print ISSN: 1144-0546
• Electronic ISSN: 1369-9261
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 42
• Issue: 12
• DOI: https://doi.org/10.1039/C8NJ00418H
• Public URL: https://nottingham-repository.worktribe.com/output/939883
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2018/NJ/C8NJ00418H#!divAbstract
• Contract Date: Jul 5, 2018