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Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity

Mondal, Satyajit; Chakraborty, Moumita; Mondal, Antu; Pakhira, Bholanath; Blake, Alexander J.; Sinn, Ekkehard; Chattopadhyay, Shyamal Kumar

Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity Thumbnail


Authors

Satyajit Mondal

Moumita Chakraborty

Antu Mondal

Bholanath Pakhira

Alexander J. Blake

Ekkehard Sinn

Shyamal Kumar Chattopadhyay



Abstract

Two new Cu(II) complexes [Cu(L1)(N3)](1) and [Cu(L1)(NCS)]n(2), where HL1 ((E)-4-((2(dimethylamino)ethylimino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol) is a N,N,O-donor Schiff base ligand, have been synthesized. These complexes were characterized on the basis of spectroscopic, electrochemical, and other physicochemical properties. X-ray crystal structure determination reveals that in complex 1, Cu(II) is in a square planar geometry with the N,N,O-donor ligand and a terminally coordinated azide ion. In complex 2, however, Cu(II) assumes a square pyramidal geometry, and apart from the tridentate Schiff base ligand there is a thiocyanate ion, which acts in a μ1,3-bridging mode, connecting adjacent Cu(II) atoms in an axial-equatorial fashion forming an one dimensional chain. Cyclic voltammetry shows that complexes undergo Cu(II)/Cu(I) reductions at −0.40 to −0.55V followed by imine reduction at around −0.7V. Cu(I)/Cu(0) reduction is observed at approximately −0.9V. Complex 1 also shows appreciable catalytic activity for the aerial oxidation of 3,5 DTBCH2 to DTBQ (catecholase activity). Both the complexes also show strong binding affinity towards calf-thymus DNA.

Citation

Mondal, S., Chakraborty, M., Mondal, A., Pakhira, B., Blake, A. J., Sinn, E., & Chattopadhyay, S. K. (2018). Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity. New Journal of Chemistry, 42(12), https://doi.org/10.1039/C8NJ00418H

Journal Article Type Article
Acceptance Date Apr 16, 2018
Online Publication Date Apr 18, 2018
Publication Date Jun 21, 2018
Deposit Date Jul 5, 2018
Publicly Available Date Apr 19, 2019
Journal New Journal of Chemistry
Print ISSN 1144-0546
Electronic ISSN 1369-9261
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 42
Issue 12
DOI https://doi.org/10.1039/C8NJ00418H
Public URL https://nottingham-repository.worktribe.com/output/939883
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2018/NJ/C8NJ00418H#!divAbstract

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