Skip to main content

Research Repository

Advanced Search

Star-shaped poly(oligoethylene glycol) copolymer-based gels: thermo-responsive behaviour and bioapplicability for risedronate intranasal delivery

Soliman, Mahmoud E.; Elmowafy, Enas; Casettari, Luca; Alexander, Cameron

Star-shaped poly(oligoethylene glycol) copolymer-based gels: thermo-responsive behaviour and bioapplicability for risedronate intranasal delivery Thumbnail


Authors

Mahmoud E. Soliman

Enas Elmowafy

Luca Casettari



Abstract

The aim of this work was to obtain an intranasal delivery system with improved mechanical and mucoadhesive properties that could provide prolonged retention time for the delivery of risedronate (RS). For this, novel in situ forming gels comprising thermo-responsive star-shaped polymers, utilizing either polyethylene glycol methyl ether (PEGMA-ME 188, Mn 188) or polyethylene glycol ethyl ether (PEGMA-EE 246, Mn 246), with polyethylene glycol methyl ether (PEGMA-ME 475, Mn 475), were synthesized and characterized. RS was trapped in the selected gel-forming solutions at a concentration of 0.2% w/v. The pH, rheological properties, in vitro drug release, ex vivo permeation as well as mucoadhesion were also examined. MTT assays were conducted to verify nasal tolerability of the developed formulations. Initial in vivo studies were carried out to evaluate anti-osteoporotic activity in a glucocorticoid induced osteoporosis model in rats. The results showed successful development of thermo-sensitive formulations with favorable mechanical properties at 37 °C, which formed non-irritant, mucoadhesive porous networks, facilitating nasal RS delivery. Moreover, sustained release of RS, augmented permeability and marked anti-osteoporotic efficacy as compared to intranasal (IN) and intravenous (IV) RS solutions were realized. The combined results show that the in situ gels should have promising application as nasal drug delivery systems.

Journal Article Type Article
Acceptance Date Mar 27, 2018
Online Publication Date Mar 28, 2018
Publication Date May 30, 2018
Deposit Date Jun 13, 2018
Publicly Available Date Mar 29, 2019
Journal International Journal of Pharmaceutics
Print ISSN 0378-5173
Electronic ISSN 1873-3476
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 543
Issue 1-2
Pages 224-233
DOI https://doi.org/10.1016/j.ijpharm.2018.03.053
Keywords Nasal delivery; Thermo-responsive star-shaped polymers; Risedronate; Thermogel cytocompatability; Antiosteoporotic activity
Public URL https://nottingham-repository.worktribe.com/output/934917
Publisher URL http://dx.doi.org/10.1016/j.ijpharm.2018.03.053

Files





You might also like



Downloadable Citations