Skip to main content

Research Repository

Advanced Search

A new human delayed-matching-to-place test in a virtual environment reverse-translated from the rodent watermaze paradigm: characterization of performance measures and sex differences

Buckley, Matthew G.; Bast, Tobias

Authors

Matthew G. Buckley



Abstract

Watermaze tests of place learning and memory in rodents, and corresponding reverse translated human paradigms in real or virtual environments, are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowing for incremental learning of the place with reference to distal cues surrounding the circular, featureless maze. Although the hippocampus is involved in incremental place learning, rodent studies have shown that the delayed-matching-to-place (DMP) watermaze test is a more sensitive assay of hippocampal function. On the DMP test, the goal location changes every 4 trials, requiring the rapid updating of place memory. Here, we developed a virtual DMP test reverse translated from the rat watermaze DMP paradigm. In two replications, participants showed 1-trial place learning, evidenced by marked latency and path length savings between trials 1 and 2 to the same goal location, and by search preference for the vicinity of the goal when trial 2 was run as probe trial (during which the goal was removed). Performance was remarkably similar to rats’ performance on the watermaze DMP test. In both replications, male participants showed greater savings and search preferences compared to female participants. Male participants also showed better mental rotation performance, although mental rotation scores did not consistently correlate with DMP performance measures, pointing to distinct neurocognitive mechanisms. The remarkable similarity between rodent and human DMP performance suggests similar underlying neuro-psychological mechanisms, including hippocampus dependence. The new virtual DMP test may, therefore, provide a sensitive tool to probe human hippocampal function.

Citation

Buckley, M. G., & Bast, T. (2018). A new human delayed-matching-to-place test in a virtual environment reverse-translated from the rodent watermaze paradigm: characterization of performance measures and sex differences. Hippocampus, 28(11), 796-812. doi:10.1002/hipo.22992

Journal Article Type Article
Acceptance Date May 27, 2018
Online Publication Date Nov 19, 2018
Publication Date Nov 19, 2018
Deposit Date May 29, 2018
Publicly Available Date Nov 20, 2019
Journal Hippocampus
Print ISSN 1050-9631
Electronic ISSN 1098-1063
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 28
Issue 11
Pages 796-812
DOI https://doi.org/10.1002/hipo.22992
Keywords Spatial; Learning and memory; Hippocampus; Water maze; Translational
Public URL http://eprints.nottingham.ac.uk/id/eprint/52064
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1002/hipo.22992
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article: Buckley MG, Bast T. A new human delayed‐matching‐to‐place test in a virtual environment reverse‐translated from the rodent watermaze paradigm: Characterization of performance measures and sex differences. Hippocampus. 2018; 1–17. https://doi.org/10.1002/hipo.22992 which has been published in final form at https://doi.org/10.1002/hipo.22992. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions

Files


BuckleyBast2018HippocampusR1.pdf (1.5 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





You might also like



Downloadable Citations