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Whole brain comparative anatomy using connectivity blueprints

Mars, Rogier B.; Sotiropoulos, Stamatios N.; Passingham, Richard E.; Sallet, Jerome; Verhagen, Lennart; Khrapitchev, Alexandre A.; Sibson, Nicola; Jbabdi, Saad

Authors

Rogier B. Mars

Stamatios N. Sotiropoulos

Richard E. Passingham

Jerome Sallet

Lennart Verhagen

Alexandre A. Khrapitchev

Nicola Sibson

Saad Jbabdi

Abstract

Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex based on a set of white matter tracts that can be anatomically matched across species. The blueprints provide a common reference space that allows us to navigate between brains of different species, identify homologous cortical areas, or to transform whole cortical maps from one species to the other. Specializations are cast within this framework as deviations between the species’ blueprints. We illustrate how this approach can be used to compare human and macaque brains.

Journal Article Type Article
Journal eLife
Electronic ISSN 2050-084X
Publisher eLife Sciences Publications
Peer Reviewed Peer Reviewed
Volume 7
Article Number e35237
Institution Citation Mars, R. B., Sotiropoulos, S. N., Passingham, R. E., Sallet, J., Verhagen, L., Khrapitchev, A. A., …Jbabdi, S. (in press). Whole brain comparative anatomy using connectivity blueprints. eLife, 7, doi:10.7554/eLife.35237. ISSN 2050-084X
DOI https://doi.org/10.7554/eLife.35237
Publisher URL https://elifesciences.org/articles/35237
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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