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Whole brain comparative anatomy using connectivity blueprints

Mars, Rogier B.; Sotiropoulos, Stamatios N.; Passingham, Richard E.; Sallet, Jerome; Verhagen, Lennart; Khrapitchev, Alexandre A.; Sibson, Nicola; Jbabdi, Saad

Authors

Rogier B. Mars

Richard E. Passingham

Jerome Sallet

Lennart Verhagen

Alexandre A. Khrapitchev

Nicola Sibson

Saad Jbabdi



Abstract

Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex based on a set of white matter tracts that can be anatomically matched across species. The blueprints provide a common reference space that allows us to navigate between brains of different species, identify homologous cortical areas, or to transform whole cortical maps from one species to the other. Specializations are cast within this framework as deviations between the species’ blueprints. We illustrate how this approach can be used to compare human and macaque brains.

Citation

Mars, R. B., Sotiropoulos, S. N., Passingham, R. E., Sallet, J., Verhagen, L., Khrapitchev, A. A., …Jbabdi, S. (in press). Whole brain comparative anatomy using connectivity blueprints. eLife, 7, https://doi.org/10.7554/eLife.35237

Journal Article Type Article
Acceptance Date May 7, 2018
Online Publication Date May 11, 2018
Deposit Date May 8, 2018
Publicly Available Date May 11, 2018
Journal eLife
Electronic ISSN 2050-084X
Publisher eLife Sciences Publications
Peer Reviewed Peer Reviewed
Volume 7
Article Number e35237
DOI https://doi.org/10.7554/eLife.35237
Public URL http://eprints.nottingham.ac.uk/id/eprint/51616
Publisher URL https://elifesciences.org/articles/35237
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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