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Upscaling Diffusion Through First-Order Volumetric Sinks: A Homogenization of Bacterial Nutrient Uptake

Dalwadi, Mohit P.; Wang, Yanming; King, John R.; Minton, Nigel P.

Authors

Mohit P. Dalwadi

YANMING WANG YANMING.WANG@NOTTINGHAM.AC.UK
Assistant Professor in Environmentalprocess Engineering

JOHN KING john.king@nottingham.ac.uk
Professor of Theoretical Mechanics

NIGEL MINTON nigel.minton@nottingham.ac.uk
Professor of Appliedmolecular Microbiology



Abstract

In mathematical models that include nutrient delivery to bacteria, it is prohibitively expensive to include a pointwise nutrient uptake within small bacterial regions over bioreactor length-scales, and so such models often impose an effective uptake instead. In this paper, we systematically investigate how the effective uptake should scale with bacterial size and other microscale properties under first-order uptake kinetics. We homogenize the unsteady problem of nutrient diffusing through a locally periodic array of spherical bacteria, within which it is absorbed. We introduce a general model that could also be applied to other single-cell microorganisms, such as cyanobacteria, microalgae, protozoa, and yeast and we consider generalizations to arbitrary bacterial shapes, including some analytic results for ellipsoidal bacteria. We explore in detail the three distinguished limits of the system on the timescale of diffusion over the macroscale. When the bacterial size is of the same order as the distance between them, the effective uptake has two limiting behaviours, scaling with the bacterial volume for weak uptake and with the bacterial surface area for strong uptake. We derive the function that smoothly transitions between these two behaviours as the system parameters vary. Additionally, we explore the distinguished limit in which bacteria are much smaller than the distance between them and have a very strong uptake. In this limit, we find that the effective uptake is bounded above as the uptake rate grows without bound; we are able to quantify this and characterise the transition to the other limits we consider.

Citation

Dalwadi, M. P., Wang, Y., King, J. R., & Minton, N. P. (2018). Upscaling Diffusion Through First-Order Volumetric Sinks: A Homogenization of Bacterial Nutrient Uptake. SIAM Journal on Applied Mathematics, 78(3), 1300-1329. https://doi.org/10.1137/17m1138625

Journal Article Type Article
Acceptance Date Feb 21, 2018
Online Publication Date May 3, 2018
Publication Date 2018-01
Deposit Date Feb 23, 2018
Publicly Available Date Feb 23, 2018
Journal SIAM Journal on Applied Mathematics
Print ISSN 0036-1399
Electronic ISSN 1095-712X
Publisher Society for Industrial and Applied Mathematics
Peer Reviewed Peer Reviewed
Volume 78
Issue 3
Pages 1300-1329
DOI https://doi.org/10.1137/17m1138625
Keywords bacterial uptake, multiscale, distinguished limits, effective uptake
Public URL http://eprints.nottingham.ac.uk/id/eprint/49962
Publisher URL https://epubs.siam.org/doi/10.1137/17M1138625
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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