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Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Horsburgh, Karen; Wardlaw, Joanna M.; van Agtmael, Tom; Allan, Stuart M.; Ashford, Mike L.J.; Bath, Philip M.; Brown, Rosalind; Berwick, Jason; Cader, M. Zameel; Carare, Roxana O.; Davis, John B.; Duncombe, Jessica; Farr, Tracy D.; Fowler, Jill H.; Goense, Jozien; Granata, Alessandra; Hall, Catherine N.; Hainsworth, Atticus H.; Harvey, Adam; Hawkes, Cheryl A.; Joutel, Anne; Kalaria, Rajesh N.; Kehoe, Patrick G.; Lawrence, Catherine B.; Lockhart, Andy; Love, Seth; Macleod, Malcolm R.; Macrae, I. Mhairi; Markus, Hugh S.; McCabe, Chris; McColl, Barry W.; Meakin, Paul J.; Miller, Alyson; Nedergaard, Maiken; O'Sullivan, Michael; Quinn, Terry J.; Rajani, Rikesh; Saksida, Lisa M.; Smith, Colin; Smith, Kenneth J.; Touyz, Rhian M.; Trueman, Rebecca C.; Wang, Tao; Williams, Anna; Williams, Steven C.R.; Work, Lorraine M.


Karen Horsburgh

Joanna M. Wardlaw

Tom van Agtmael

Stuart M. Allan

Mike L.J. Ashford

Stroke Association Professor of Stroke Medicine

Rosalind Brown

Jason Berwick

M. Zameel Cader

Roxana O. Carare

John B. Davis

Jessica Duncombe

Jill H. Fowler

Jozien Goense

Alessandra Granata

Catherine N. Hall

Atticus H. Hainsworth

Adam Harvey

Cheryl A. Hawkes

Anne Joutel

Rajesh N. Kalaria

Patrick G. Kehoe

Catherine B. Lawrence

Andy Lockhart

Seth Love

Malcolm R. Macleod

I. Mhairi Macrae

Hugh S. Markus

Chris McCabe

Barry W. McColl

Paul J. Meakin

Alyson Miller

Maiken Nedergaard

Michael O'Sullivan

Terry J. Quinn

Rikesh Rajani

Lisa M. Saksida

Colin Smith

Kenneth J. Smith

Rhian M. Touyz

Tao Wang

Anna Williams

Steven C.R. Williams

Lorraine M. Work


Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.


Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L., Bath, P. M., …Work, L. M. (2018). Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8),

Journal Article Type Article
Acceptance Date Feb 21, 2018
Publication Date Apr 30, 2018
Deposit Date May 8, 2018
Publicly Available Date May 1, 2019
Journal Clinical Science
Print ISSN 0143-5221
Electronic ISSN 0143-5221
Publisher Portland Press
Peer Reviewed Peer Reviewed
Volume 132
Issue 8
Public URL
Publisher URL


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