Glycaemic control in type 2 diabetes patients and its predictors: a retrospective database study at a tertiary care diabetes centre in Ningbo, China

Li, Jialin; Chattopadhyay, Kaushik; Xu, Miao; Chen, Yanshu; Hu, Fangfang; Chu, Jianping; Li, Li

Abstract

Objectives: The objectives of the study were to assess glycaemic control in patients with type 2 diabetes (T2DM) at a tertiary care diabetes centre in Ningbo, China and to determine factors that independently predict their glycaemic control.

Design: Retrospective cross-sectional study using an existing database, the Diabetes Information Management System.

Setting: Tertiary care diabetes centre in Ningbo, China.

Participants: The study included adult patients with T2DM, registered and received treatment at the diabetes centre for at least six consecutive months. The study inclusion criteria were satisfied by 1387 patients, from 1 July 2012 to 30 June 2017.

Primary outcome measure: Glycaemic control (poor was defined as glycated haemoglobin (HbA1c)>=7% or fasting blood glucose (FBG)>7.0 mmol/L).

Results: In terms of HbA1c and FBG, the 5-year period prevalence of poor glycaemic control was 50.3% and 57.3%, respectively. In terms of HbA1c and FBG, the odds of poor glycaemic control increased with the duration of T2DM (>1 to 2 years: OR 1.84, 95% CI 1.06 to 3.19; >2 to 4 years: 3.32, 1.88 to 5.85 and >4 years: 5.98, 4.09 to 8.75 and >1 to 2 years: 2.10, 1.22 to 3.62; >2 to 4 years: 2.48, 1.42 to 4.34 and >4 years: 3.34, 2.32 to 4.80) and were higher in patients residing in rural areas (1.68, 1.24 to 2.28 and 1.42, 1.06 to 1.91), with hyperlipidaemia (1.57, 1.12 to 2.19 and 1.68, 1.21 to 2.33), on diet, physical activity and oral hypoglycaemic drug (OHD) as part of their T2DM therapeutic regimen (1.80, 1.01 to 3.23 and 2.40, 1.36 to 4.26) and on diet, physical activity, OHD and insulin (2.47, 1.38 to 4.41 and 2.78, 1.58 to 4.92), respectively.

Conclusions: More than half of patients with T2DM at the diabetes centre in Ningbo, China have poor glycaemic control, and the predictors of glycaemic control were identified. The study findings could be taken into consideration in future interventional studies aimed at improving glycaemic control in these patients.

Citation

Li, J., Chattopadhyay, K., Xu, M., Chen, Y., Hu, F., Chu, J., & Li, L. (in press). Glycaemic control in type 2 diabetes patients and its predictors: a retrospective database study at a tertiary care diabetes centre in Ningbo, China. BMJ Open, 8(3), Article e019697. https://doi.org/10.1136/bmjopen-2017-019697

• Journal Article Type: Article
• Acceptance Date: Mar 6, 2018
• Online Publication Date: Mar 25, 2018
• Deposit Date: Mar 27, 2018
• Publicly Available Date: Mar 27, 2018
• Journal: BMJ Open
• Electronic ISSN: 2044-6055
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 3
• Article Number: e019697
• DOI: https://doi.org/10.1136/bmjopen-2017-019697
• Public URL: https://nottingham-repository.worktribe.com/output/921745
• Publisher URL: http://bmjopen.bmj.com/content/8/3/e019697
• Contract Date: Mar 27, 2018