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Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort

Mukherjee, A.; Russell, R.; Chin, Suet-Feung; Liu, B.; Rueda, O.M.; Ali, H.R.; Turashvili, G.; Mahler-Araujo, B.; Ellis, I.O.; Aparicio, S.; Caldas, C.; Provenzano, E.

Authors

A. Mukherjee

R. Russell

Suet-Feung Chin

B. Liu

O.M. Rueda

H.R. Ali

G. Turashvili

B. Mahler-Araujo

S. Aparicio

C. Caldas

E. Provenzano



Abstract

The integration of genomic and transcriptomic profiles of 2000 breast tumours from the METABRIC [Molecular Taxonomy of Breast Cancer International Consortium] cohort revealed ten subtypes, termed integrative clusters (IntClust/s), characterised by distinct genomic drivers. Central histopathology (N = 1643) review was undertaken to explore the relationship between these ten molecular subtypes and traditional clinicopathological features. IntClust subtypes were significantly associated with histological type, tumour grade, receptor status, and lymphocytic infiltration (p 

Journal Article Type Article
Publication Date Mar 7, 2018
Journal npj Breast Cancer
Electronic ISSN 2374-4677
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 4
Issue 1
Article Number 5
APA6 Citation Mukherjee, A., Russell, R., Chin, S., Liu, B., Rueda, O., Ali, H., …Provenzano, E. (2018). Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort. npj Breast Cancer, 4(1), doi:10.1038/s41523-018-0056-8
DOI https://doi.org/10.1038/s41523-018-0056-8
Publisher URL https://www.nature.com/articles/s41523-018-0056-8
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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