Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort

Mukherjee, A.; Russell, R.; Chin, Suet-Feung; Liu, B.; Rueda, O.M.; Ali, H.R.; Turashvili, G.; Mahler-Araujo, B.; Ellis, I.O.; Aparicio, S.; Caldas, C.; Provenzano, E.

Abstract

The integration of genomic and transcriptomic profiles of 2000 breast tumours from the METABRIC [Molecular Taxonomy of Breast Cancer International Consortium] cohort revealed ten subtypes, termed integrative clusters (IntClust/s), characterised by distinct genomic drivers. Central histopathology (N = 1643) review was undertaken to explore the relationship between these ten molecular subtypes and traditional clinicopathological features. IntClust subtypes were significantly associated with histological type, tumour grade, receptor status, and lymphocytic infiltration (p 

• Journal Article Type: Article
• Acceptance Date: Jan 18, 2018
• Online Publication Date: Mar 7, 2018
• Publication Date: Mar 7, 2018
• Deposit Date: Mar 7, 2018
• Publicly Available Date: Mar 7, 2018
• Journal: npj Breast Cancer
• Electronic ISSN: 2374-4677
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 1
• Article Number: 5
• DOI: https://doi.org/10.1038/s41523-018-0056-8
• Public URL: https://nottingham-repository.worktribe.com/output/919308
• Publisher URL: https://www.nature.com/articles/s41523-018-0056-8