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Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception

Muir, Ronan Davidson; Liu, Ge; Khan, Raheela; Shmygol, Anatoly; Quenby, Siobhan; Gibson, Robert Alan; Muhlhausler, Beverly; Elmes, Matthew

Authors

Ronan Davidson Muir ronandmuir@aol.com

Ge Liu ge.liu@adelaide.edu.au

RAHEELA KHAN RAHEELA.KHAN@NOTTINGHAM.AC.UK
Professor of Cellular Physiology

Anatoly Shmygol a.shmygol@uaeu.ac.ae

Siobhan Quenby S.Quenby@warwick.ac.uk

Robert Alan Gibson robert.gibson@adelaide.edu.au

Beverly Muhlhausler beverly.muhlhausler@adelaide.edu.au



Abstract

Maternal obesity is associated with prolonged and dysfunctional labour, potentially through decreased synthesis of prostaglandins that stimulate myometrial contractions. We assessed the impact of maternal obesity on concentrations of precursor fatty acids (FA) for prostaglandin synthesis and whether any changes could be reversed by improved nutrition post-conception. Wistar rats were fed control (CON) or High-Fat, High-cholesterol (HFHC) diets 6 weeks before mating. At conception half the dams switched diets providing 4 dietary groups: (1) CON, (2) HFHC, (3) CON-HFHC or (4) HFHC-CON. During parturition rats were euthanized and FA composition of plasma, liver and uterus determined. Visceral fat was doubled in rats exposed to the HFHC diet prior to and/or during pregnancy compared to CON. HFHC diet increased MUFAs but decreased omega-3 and omega-6 PUFAs in plasma and liver. Uterine omega-3 FA concentrations were halved in HFHC versus CON rats, but all other FAs were similar. Switching from HFHC to CON diet at conception restored all FA profles to those seen in CON rats. The increased MUFA and decreased PUFA concentrations in obese HFHC dams may contribute to aberrant prostaglandin synthesis and dysfunctional myometrial activity and it may be possible to reverse these changes, and potentially improve labour outcomes, by improving nutrition at conception.

Citation

Muir, R. D., Liu, G., Khan, R., Shmygol, A., Quenby, S., Gibson, R. A., …Elmes, M. (2018). Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception. Scientific Reports, 8, https://doi.org/10.1038/s41598-018-21809-9

Journal Article Type Article
Acceptance Date Feb 12, 2018
Publication Date Feb 21, 2018
Deposit Date Feb 21, 2018
Publicly Available Date Feb 21, 2018
Journal Scientific Reports
Print ISSN 2045-2322
Electronic ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 8
Article Number 3389
DOI https://doi.org/10.1038/s41598-018-21809-9
Keywords Maternal obesity; Polyunsaturated fatty acids; Change of diet at conception; Uterus; Improved nutrition
Public URL http://eprints.nottingham.ac.uk/id/eprint/49910
Publisher URL https://www.nature.com/articles/s41598-018-21809-9.pdf
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Elmes Scientific Reports Paper Feb 2018.pdf (1.2 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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