Skip to main content

Research Repository

Advanced Search

Drug delivery across length scales

Delcassian, Derfogail; Patel, Asha K.; Cortinas, Abel B.; Langer, Robert

Drug delivery across length scales Thumbnail


Authors

Derfogail Delcassian

Asha K. Patel

Abel B. Cortinas

Robert Langer



Abstract

Over the last century, there has been a dramatic change in the nature of therapeutic, biologically active molecules available to treat disease. Therapies have evolved from extracted natural products towards rationally designed biomolecules, including small molecules, engineered proteins and nucleic acids. The use of potent drugs which target specific organs, cells or biochemical pathways, necessitates new tools which can enable controlled delivery and dosing of these therapeutics to their biological targets. Here, we review the miniaturisation of drug delivery systems from the macro to nano-scale, focussing on controlled dosing and controlled targeting as two key parameters in drug delivery device design. We describe how the miniaturisation of these devices enables the move from repeated, systemic dosing, to on-demand, targeted delivery of therapeutic drugs and highlight areas of focus for the future.

Citation

Delcassian, D., Patel, A. K., Cortinas, A. B., & Langer, R. (2019). Drug delivery across length scales. Journal of Drug Targeting, 27(3), 229-243. https://doi.org/10.1080/1061186X.2018.1438440

Journal Article Type Article
Acceptance Date Feb 5, 2018
Online Publication Date Feb 20, 2018
Publication Date Feb 20, 2019
Deposit Date Apr 25, 2018
Publicly Available Date Mar 28, 2024
Journal Journal of Drug Targeting
Print ISSN 1061-186X
Electronic ISSN 1029-2330
Publisher Informa Healthcare
Peer Reviewed Peer Reviewed
Volume 27
Issue 3
Pages 229-243
DOI https://doi.org/10.1080/1061186X.2018.1438440
Keywords Drug delivery, length scale, targeting, macro, micro, nano
Public URL https://nottingham-repository.worktribe.com/output/912380
Publisher URL https://www.tandfonline.com/doi/full/10.1080/1061186X.2018.1438440

Files





You might also like



Downloadable Citations