Skip to main content

Research Repository

Advanced Search

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)

Barratt, Shaney L.; Blythe, Thomas; Ourradi, Khadija; Jarrett, Caroline; Welsh, Gavin I.; Bates, David O.; Millar, Ann B.

Authors

Shaney L. Barratt

Thomas Blythe

Khadija Ourradi

Caroline Jarrett

Gavin I. Welsh

Ann B. Millar



Abstract

Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of hypoxia and hyperoxia in the development and progression of IPF has not been explored. In normal lung (NF) and IPF-derived fibroblasts (FF) VEGF-Aa protein expression was upregulated by hypoxia, mediated through activation of VEGF-Aa gene transcription. VEGF-A receptors and co-receptors were differentially expressed by hypoxia and hyperoxia. Our data supports a potential role for hypoxia, hyperoxia and VEGF-Aa isoforms as drivers of fibrogenesis.

Citation

Barratt, S. L., Blythe, T., Ourradi, K., Jarrett, C., Welsh, G. I., Bates, D. O., & Millar, A. B. (in press). Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF). Respiratory Research, 19, https://doi.org/10.1186/s12931-017-0711-x

Journal Article Type Article
Acceptance Date Dec 26, 2017
Online Publication Date Jan 15, 2018
Deposit Date Mar 5, 2018
Publicly Available Date Mar 5, 2018
Journal Respiratory Research
Print ISSN 1465-9921
Electronic ISSN 1465-9921
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 19
DOI https://doi.org/10.1186/s12931-017-0711-x
Keywords Interstitial lung disease, Vascular endothelial growth factor, Hypoxia, Idiopathic pulmonary fibrosis
Public URL http://eprints.nottingham.ac.uk/id/eprint/50178
Publisher URL https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-017-0711-x
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

Files


document-1.pdf (412 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





You might also like



Downloadable Citations