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Presence of time-dependent diffusion in the brachial plexus

Mahbub, Zaid B.; Peters, Andrew M.; Gowland, Penny A.

Authors

Zaid B. Mahbub

Andrew M. Peters

Penny A. Gowland



Abstract

Purpose

This work describes the development of a method to measure the variation of apparent diffusion coefficient (ADC) with diffusion time (Δ) in the brachial plexus, as a potential method of probing microstructure.
Methods

Diffusion-weighted MRI with body signal suppression was used to highlight the nerves from surrounding tissues, and sequence parameters were optimized for sensitivity to change with diffusion time. A porous media-restricted diffusion model based on the Latour-Mitra equation was fitted to the diffusion time-dependent ADC data from the brachial plexus nerves and cord.
Results

The ADC was observed to reduce at long diffusion times, confirming that diffusion was restricted in the nerves and cord in healthy subjects. T2 of the nerves was measured to be 80 ± 5 ms, the diffusion coefficient was found to vary from (1.5 ± 0.1) × 10−3 mm2/s at a diffusion time of 18.3 ms to (1.0 ± 0.2) × 10−3 mm2/s at a diffusion time of 81.3 ms.
Conclusion

A novel method of probing restricted diffusion in the brachial plexus was developed. Resulting parameters were comparable with values obtained previously on biological systems.

Journal Article Type Article
Publication Date 2018-02
Journal Magnetic Resonance in Medicine
Print ISSN 0740-3194
Electronic ISSN 1522-2594
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 79
Issue 2
Pages 789-795
APA6 Citation Mahbub, Z. B., Peters, A. M., & Gowland, P. A. (2018). Presence of time-dependent diffusion in the brachial plexus. Magnetic Resonance in Medicine, 79(2), 789-795. https://doi.org/10.1002/mrm.26733
DOI https://doi.org/10.1002/mrm.26733
Keywords brachial plexus; ADC; diffusion time; restricted diffusion
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/mrm.26733/full
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf


MRM_26733%20%28002%29.pdf (910 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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