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British Society of Gastroenterology guidelines on the management of functional dyspepsia

Black, Christopher J.; Paine, Peter A; Agrawal, Anurag; Aziz, Imran; Eugenicos, Maria P; Houghton, Lesley A.; Hungin, Pali; Overshott, Ross; Vasant, Dipesh H; Rudd, Sheryl; Winning, Richard C; Corsetti, Maura; Ford, Alexander C.

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Christopher J. Black

Peter A Paine

Anurag Agrawal

Imran Aziz

Maria P Eugenicos

Lesley A. Houghton

Pali Hungin

Ross Overshott

Dipesh H Vasant

Sheryl Rudd

Richard C Winning

Clinical Associate Professor

Alexander C. Ford


Functional dyspepsia (FD) is a common disorder of gut-brain interaction, affecting approximately 7% of individuals in the community, with most patients managed in primary care. The last British Society of Gastroenterology (BSG) guideline for the management of dyspepsia was published in 1996. In the interim, substantial advances have been made in understanding the complex pathophysiology of FD, and there has been a considerable amount of new evidence published concerning its diagnosis and classification, with the advent of the Rome IV criteria, and management. The primary aim of this guideline, commissioned by the BSG, is to review and summarise the current evidence to inform and guide clinical practice, by providing a practical framework for evidence-based diagnosis and treatment of patients. The approach to investigating the patient presenting with dyspepsia is discussed, and efficacy of drugs in FD summarised based on evidence derived from a comprehensive search of the medical literature, which was used to inform an update of a series of pairwise and network meta-Analyses. Specific recommendations have been made according to the Grading of Recommendations Assessment, Development and Evaluation system. These provide both the strength of the recommendations and the overall quality of evidence. Finally, in this guideline, we consider novel treatments that are in development, as well as highlighting areas of unmet need and priorities for future research.


Black, C. J., Paine, P. A., Agrawal, A., Aziz, I., Eugenicos, M. P., Houghton, L. A., …Ford, A. C. (2022). British Society of Gastroenterology guidelines on the management of functional dyspepsia. Gut, 71(9), 1697-1723.

Journal Article Type Article
Acceptance Date Jun 21, 2022
Online Publication Date Jul 7, 2022
Publication Date 2022-09
Deposit Date Jul 12, 2022
Publicly Available Date Jul 22, 2022
Journal Gut
Print ISSN 0017-5749
Electronic ISSN 1468-3288
Publisher BMJ
Peer Reviewed Peer Reviewed
Volume 71
Issue 9
Pages 1697-1723
Keywords Gastroenterology
Public URL
Publisher URL


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