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Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics

Simpson, Siobhan; Dunning, Mark D.; de Brot, Simone; Grau-Roma, Llorenc; Mongan, Nigel P.; Rutland, Catrin S.

Authors

Siobhan Simpson

Simone de Brot

Llorenc Grau-Roma

NIGEL MONGAN nigel.mongan@nottingham.ac.uk
Professor of Oncology



Abstract

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, one year survival rates are only around ~45%. Improved and novel treatment regimens are urgently required to improve survival in both humans and dogs with OSA. Utilising information from genetic studies could assist in this in both species, with the higher incidence rates in dogs contributing to the dog population being a good model of human disease. This review compares the clinical characteristics, gross morphology and histopathology, aetiology, epidemiology, and genetics of canine and human osteosarcoma. Finally, the current position of canine osteosarcoma genetic research is discussed and areas for additional work within the canine population are identified.

Citation

Simpson, S., Dunning, M. D., de Brot, S., Grau-Roma, L., Mongan, N. P., & Rutland, C. S. (2017). Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics. Acta Veterinaria Scandinavica, 59, Article 71. https://doi.org/10.1186/s13028-017-0341-9

Journal Article Type Article
Acceptance Date Oct 18, 2017
Publication Date Oct 24, 2017
Deposit Date Oct 25, 2017
Publicly Available Date Mar 28, 2024
Journal Acta Veterinaria Scandinavica
Electronic ISSN 1751-0147
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 59
Article Number 71
DOI https://doi.org/10.1186/s13028-017-0341-9
Keywords Canine; Human; Osteosarcoma; Bone cancer; Treatment; Genetics; Molecular; Diagnostics
Public URL https://nottingham-repository.worktribe.com/output/889576
Publisher URL https://actavetscand.biomedcentral.com/articles/10.1186/s13028-017-0341-9

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