Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports
Kovac, Milomir; Litvin, Yaroslav A.; Aliev, Ruslan O.; Zakirova, Elena Yu; Rutland, Catrin S.; Kiyasov, Andrey; Rizvanov, Albert A.
Yaroslav A. Litvin
Ruslan O. Aliev
Elena Yu Zakirova
CATRIN RUTLAND email@example.com
Albert A. Rizvanov
In this clinical study, for the first time we used the direct gene therapy to restore severe injuries of the suspensory ligament branch and superficial digital flexor tendon in horses (Equus caballus). We injected the plasmid DNA encoding two therapeutic species-specific growth factors: vascular endothelial growth factor 164 and fibroblast growth factor 2 at the site of injury in the suspensory ligament branch and tendon. Treatment effects were evaluated with the use of clinical observation and ultrasound imaging during a period of a few months. We showed that gene therapy used within a period of 2–3 months after the injury resulted in the complete recovery of functions and full restoration of the severely damaged suspensory ligament and superficial digital flexor tendon.
Kovac, M., Litvin, Y. A., Aliev, R. O., Zakirova, E. Y., Rutland, C. S., Kiyasov, A., & Rizvanov, A. A. (2017). Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports. Frontiers in Veterinary Science, 4(168), https://doi.org/10.3389/fvets.2017.00168
|Journal Article Type||Article|
|Acceptance Date||Sep 25, 2017|
|Publication Date||Oct 10, 2017|
|Deposit Date||Oct 10, 2017|
|Publicly Available Date||Oct 10, 2017|
|Journal||Frontiers in Veterinary Science|
|Peer Reviewed||Peer Reviewed|
|Keywords||Gene therapy, Tendon, Suspensory ligament, Horse, Vascular endothelial growth factor, Fibroblast
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Publisher Licence URL
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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