From UTP to AR-C118925, the discovery of a potent non nucleotide antagonist of the P2Y2 receptor

Kindon, Nicholas; Davis, Andrew; Dougall, Iain; Dixon, John; Johnson, Timothy; Walters, Iain; Thom, Steve; McKechnie, Kenneth; Meghani, Premji; Stocks, Michael

Abstract

The G protein-coupled P2Y2 receptor, activated by ATP and UTP has been reported as a potential drug target for a wide range of important clinical conditions, such as tumor metastasis, kidney disorders, and in the treatment of inflammatory conditions. However, pharmacological studies on this receptor have been impeded by the limited reported availability of stable, potent and selective P2Y2R antagonists. This article describes the design and synthesis of AR-C118925, a potent and selective non-nucleotide antagonist of the P2Y2 receptor discovered using the endogenous P2Y2R agonist UTP as the chemical starting point.

Citation

Kindon, N., Davis, A., Dougall, I., Dixon, J., Johnson, T., Walters, I., …Stocks, M. (2017). From UTP to AR-C118925, the discovery of a potent non nucleotide antagonist of the P2Y2 receptor. Bioorganic and Medicinal Chemistry Letters, 27(21), 4849-4853. https://doi.org/10.1016/j.bmcl.2017.09.043

• Journal Article Type: Article
• Acceptance Date: Sep 20, 2017
• Online Publication Date: Sep 21, 2017
• Publication Date: Nov 1, 2017
• Deposit Date: Sep 27, 2017
• Journal: Bioorganic & Medicinal Chemistry Letters
• Electronic ISSN: 1464-3405
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 27
• Issue: 21
• Pages: 4849-4853
• DOI: https://doi.org/10.1016/j.bmcl.2017.09.043
• Keywords: P2Y2; Purinergic; AR-C118925; P2; Antagonist
• Public URL: https://nottingham-repository.worktribe.com/output/883601
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0960894X17309393