L. Polledo
Hypophysitis, Panhypopituitarism, and Hypothalamitis in a Scottish Terrier Dog
Polledo, L.; Oliveira, M.; Adamany, J.; Graham, P.; Baiker, K.
Authors
M. Oliveira
J. Adamany
Dr PETER GRAHAM PETER.GRAHAM@NOTTINGHAM.AC.UK
Professor of Veterinary Clinical Pathology and Endocrinology
K. Baiker
Abstract
A 6-year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized a lesion to the forebrain and hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) of the brain revealed a rounded, well-defined, suprasellar central mass. The mass was slightly hyperintense to the cortical grey matter on T2-weighted (T2W), hypointense on T1-weighted (T1W) images and without T2* signal void. There was a central fusiform enhancement of the mass after contrast administration which raised the suspicion of a pituitary neoplasm. Rapid deterioration of the dog prevented further clinical investigations. Histopathologic examination revealed a lymphocytic panhypophysitis of unknown origin suspected autoimmune involving the hypothalamus (hypothalamitis). This is a unique case report of a dog presenting with inflammatory hypophysitis and hypothalamitis of suspected autoimmune origin with detailed clinical, MRI, histology and immunohistochemistry findings.
Citation
Polledo, L., Oliveira, M., Adamany, J., Graham, P., & Baiker, K. (2017). Hypophysitis, Panhypopituitarism, and Hypothalamitis in a Scottish Terrier Dog. Journal of Veterinary Internal Medicine, 31(5), 1527-1532. https://doi.org/10.1111/jvim.14790
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 22, 2017 |
Online Publication Date | Jul 26, 2017 |
Publication Date | Sep 14, 2017 |
Deposit Date | May 25, 2017 |
Publicly Available Date | Jul 26, 2017 |
Journal | Journal of Veterinary Internal Medicine |
Print ISSN | 0891-6640 |
Electronic ISSN | 1939-1676 |
Publisher | Wiley Open Access |
Peer Reviewed | Peer Reviewed |
Volume | 31 |
Issue | 5 |
Pages | 1527-1532 |
DOI | https://doi.org/10.1111/jvim.14790 |
Keywords | MRI; autoimmune; hypoadrenocorticism; diabetes insipidus |
Public URL | https://nottingham-repository.worktribe.com/output/882983 |
Publisher URL | http://onlinelibrary.wiley.com/doi/10.1111/jvim.14790/full |
Contract Date | May 25, 2017 |
Files
Polledo_et_al-2017-Journal_of_Veterinary_Internal_Medicine.pdf
(861 Kb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0
You might also like
Pathological findings in the pituitary glands of 201 dogs and cats
(2018)
Journal Article
Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism
(2020)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search