Hypophysitis, Panhypopituitarism, and Hypothalamitis in a Scottish Terrier Dog

Polledo, L.; Oliveira, M.; Adamany, J.; Graham, P.; Baiker, K.

Abstract

A 6-year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized a lesion to the forebrain and hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) of the brain revealed a rounded, well-defined, suprasellar central mass. The mass was slightly hyperintense to the cortical grey matter on T2-weighted (T2W), hypointense on T1-weighted (T1W) images and without T2* signal void. There was a central fusiform enhancement of the mass after contrast administration which raised the suspicion of a pituitary neoplasm. Rapid deterioration of the dog prevented further clinical investigations. Histopathologic examination revealed a lymphocytic panhypophysitis of unknown origin suspected autoimmune involving the hypothalamus (hypothalamitis). This is a unique case report of a dog presenting with inflammatory hypophysitis and hypothalamitis of suspected autoimmune origin with detailed clinical, MRI, histology and immunohistochemistry findings.

Citation

Polledo, L., Oliveira, M., Adamany, J., Graham, P., & Baiker, K. (2017). Hypophysitis, Panhypopituitarism, and Hypothalamitis in a Scottish Terrier Dog. Journal of Veterinary Internal Medicine, 31(5), 1527-1532. https://doi.org/10.1111/jvim.14790

• Journal Article Type: Article
• Acceptance Date: Jun 22, 2017
• Online Publication Date: Jul 26, 2017
• Publication Date: Sep 14, 2017
• Deposit Date: May 25, 2017
• Publicly Available Date: Jul 26, 2017
• Journal: Journal of Veterinary Internal Medicine
• Print ISSN: 0891-6640
• Electronic ISSN: 1939-1676
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• Volume: 31
• Issue: 5
• Pages: 1527-1532
• DOI: https://doi.org/10.1111/jvim.14790
• Keywords: MRI; autoimmune; hypoadrenocorticism; diabetes insipidus
• Public URL: https://nottingham-repository.worktribe.com/output/882983
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1111/jvim.14790/full