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Hypophysitis, Panhypopituitarism, and Hypothalamitis in a Scottish Terrier Dog

Polledo, L.; Oliveira, M.; Adamany, J.; Graham, P.; Baiker, K.

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L. Polledo

M. Oliveira

J. Adamany

Professor of Veterinary Clinical Pathology and Endocrinology

K. Baiker


A 6-year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized a lesion to the forebrain and hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) of the brain revealed a rounded, well-defined, suprasellar central mass. The mass was slightly hyperintense to the cortical grey matter on T2-weighted (T2W), hypointense on T1-weighted (T1W) images and without T2* signal void. There was a central fusiform enhancement of the mass after contrast administration which raised the suspicion of a pituitary neoplasm. Rapid deterioration of the dog prevented further clinical investigations. Histopathologic examination revealed a lymphocytic panhypophysitis of unknown origin suspected autoimmune involving the hypothalamus (hypothalamitis). This is a unique case report of a dog presenting with inflammatory hypophysitis and hypothalamitis of suspected autoimmune origin with detailed clinical, MRI, histology and immunohistochemistry findings.

Journal Article Type Article
Acceptance Date Jun 22, 2017
Online Publication Date Jul 26, 2017
Publication Date Sep 14, 2017
Deposit Date May 25, 2017
Publicly Available Date Jul 26, 2017
Journal Journal of Veterinary Internal Medicine
Print ISSN 0891-6640
Electronic ISSN 1939-1676
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Volume 31
Issue 5
Pages 1527-1532
Keywords MRI; autoimmune; hypoadrenocorticism; diabetes insipidus
Public URL
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