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Emotional arousal impairs association-memory: roles of amygdala and hippocampus

Madan, Christopher R.; Fujiwara, Esther; Caplan, Jeremy B.; Sommer, Tobias

Authors

Christopher R. Madan

Esther Fujiwara

Jeremy B. Caplan

Tobias Sommer



Abstract

Emotional arousal is well-known to enhance memory for individual items or events, whereas it can impair association memory. The neural mechanism of this association memory impairment by emotion is not known: In response to emotionally arousing information, amygdala activity may interfere with hippocampal associative encoding (e.g., via prefrontal cortex). Alternatively, emotional information may be harder to unitize, resulting in reduced availability of extra-hippocampal medial temporal lobe support for emotional than neutral associations. To test these opposing hypotheses, we compared neural processes underlying successful and unsuccessful encoding of emotional and neutral associations. Participants intentionally studied pairs of neutral and negative pictures (Experiments 1–3). We found reduced association-memory for negative pictures in all experiments, accompanied by item-memory increases in Experiment 2. High-resolution fMRI (Experiment 3) indicated that reductions in associative encoding of emotional information are localizable to an area in ventral-lateral amygdala, driven by attentional/salience effects in the central amygdala. Hippocampal activity was similar during both pair types, but a left hippocampal cluster related to successful encoding was observed only for negative pairs. Extra-hippocampal associative memory processes (e.g., unitization) were more effective for neutral than emotional materials. Our findings suggest that reduced emotional association memory is accompanied by increases in activity and functional coupling within the amygdala. This did not disrupt hippocampal association-memory processes, which indeed were critical for successful emotional association memory formation.

Journal Article Type Article
Publication Date Aug 1, 2017
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1095-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 156
APA6 Citation Madan, C. R., Fujiwara, E., Caplan, J. B., & Sommer, T. (2017). Emotional arousal impairs association-memory: roles of amygdala and hippocampus. NeuroImage, 156, doi:10.1016/j.neuroimage.2017.04.065
DOI https://doi.org/10.1016/j.neuroimage.2017.04.065
Publisher URL http://www.sciencedirect.com/science/article/pii/S1053811917303841
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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