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A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine

Drinkall, Emma; Wass, Matthew J.; Coffey, Tracey J.; Flynn, Robin J.

Authors

Emma Drinkall emma.drinkall1@nottingham.ac.uk

Matthew J. Wass matthew.wass@nottingham.ac.uk

Tracey J. Coffey tracey.coffey@nottingham.ac.uk

Robin J. Flynn robin.flynn@liverpool.ac.uk



Abstract

Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biopsies. IL-17A accumulated over time peaking at 9 h post-infection, with no effect of infection on IL-1β; antibiotics positively influenced IL-17A as higher levels were found in cultures with antibiotics. Infection of primary fibroblasts resulted in lower plaque formation when fibroblasts were primed with IL-17A. Our results indicate a role for IL-17A in reducing C. parvum-dependent host cell damage.

Journal Article Type Article
Journal Veterinary Immunology and Immunopathology
Print ISSN 0165-2427
Electronic ISSN 1873-2534
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 191
APA6 Citation Drinkall, E., Wass, M. J., Coffey, T. J., & Flynn, R. J. (in press). A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine. Veterinary Immunology and Immunopathology, 191, https://doi.org/10.1016/j.vetimm.2017.07.009
DOI https://doi.org/10.1016/j.vetimm.2017.07.009
Keywords Cryptosporidium parvum; Biopsy; IL-17A; Intestine; Villi; Bovine
Publisher URL http://www.sciencedirect.com/science/article/pii/S0165242717302945
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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