Emma Drinkall email@example.com
A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine
Drinkall, Emma; Wass, Matthew J.; Coffey, Tracey J.; Flynn, Robin J.
Matthew J. Wass firstname.lastname@example.org
Tracey J. Coffey email@example.com
Robin J. Flynn firstname.lastname@example.org
Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biopsies. IL-17A accumulated over time peaking at 9 h post-infection, with no effect of infection on IL-1β; antibiotics positively influenced IL-17A as higher levels were found in cultures with antibiotics. Infection of primary fibroblasts resulted in lower plaque formation when fibroblasts were primed with IL-17A. Our results indicate a role for IL-17A in reducing C. parvum-dependent host cell damage.
|Journal Article Type||Article|
|Journal||Veterinary Immunology and Immunopathology|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Drinkall, E., Wass, M. J., Coffey, T. J., & Flynn, R. J. (in press). A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine. Veterinary Immunology and Immunopathology, 191, https://doi.org/10.1016/j.vetimm.2017.07.009|
|Keywords||Cryptosporidium parvum; Biopsy; IL-17A; Intestine; Villi; Bovine|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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