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One-pot synthesis of micron-sized polybetaine particles: innovative use of supercritical carbon dioxide

Bassett, Simon P.; Birkin, Natasha A.; Jennings, James; Champman, Emma; O'Reilly, Rachel K.; Howdle, Steven M.; Willcock, Helen

Authors

Simon P. Bassett

Natasha A. Birkin

James Jennings

Emma Champman

Rachel K. O'Reilly

Helen Willcock



Abstract

Polybetaines exhibit unique properties combining anti-polyelectrolyte and low protein fouling behaviour, as well as biocompatibility. To date, the synthesis of polybetaine particles >50 nm has proved to be extremely challenging with standard emulsion and dispersion techniques being unsuccessful. Here we present the first reported synthesis of micron-sized, discrete cross-linked polybetaine particles, using polymerisation in scCO2 with methanol as a co-solvent. Discrete particles are produced only when the methanol is efficiently removed in situ using scCO2 extraction. A relatively high crosslinking agent initial concentration (10 wt%) was found to result in the most well defined particles, and particle integrity reduced as the crosslinking agent initial concentration was decreased. A monomer loading of between 3.0 × 10−2 mol L−1 and 1.8 × 10−1 mol L−1 resulted in discrete micron sized particles, with significant agglomoration occuring as the monomer loading was increased further. A spherical morphology and extremely low size dispersity was observed by SEM analysis for the optimised particles. The particles were readily re-dispersed in aqueous solution and light scattering measurements confirmed their low size dispersity.

Citation

Bassett, S. P., Birkin, N. A., Jennings, J., Champman, E., O'Reilly, R. K., Howdle, S. M., & Willcock, H. (in press). One-pot synthesis of micron-sized polybetaine particles: innovative use of supercritical carbon dioxide. Polymer Chemistry, 8, https://doi.org/10.1039/C7PY00455A

Journal Article Type Article
Acceptance Date Jul 2, 2017
Online Publication Date Jul 3, 2017
Deposit Date Oct 13, 2017
Publicly Available Date Oct 13, 2017
Journal Polymer Chemistry
Print ISSN 1759-9954
Electronic ISSN 1759-9962
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 8
DOI https://doi.org/10.1039/C7PY00455A
Public URL http://eprints.nottingham.ac.uk/id/eprint/47250
Publisher URL http://pubs.rsc.org/en/content/articlehtml/2017/py/c7py00455a
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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