Skip to main content

Research Repository

Advanced Search

Bridging the age gap in breast cancer: evaluation of decision support interventions for older women with operable breast cancer: protocol for a cluster randomised controlled trial

Collins, Karen; Reed, Malcolm; Lifford, Kate; Burton, Maria; Edwards, Adrian; Ring, Alistair; Brain, Katherine; Harder, Helena; Robinson, Thompson; Cheung, Kwok-Leung; Morgan, Jenna; Audisio, Riccardo; Ward, Susan; Richards, Paul; Martin, Charlene; Chater, Tim; Pemberton, Kirsty; Nettleship, Anthony; Murray, Christopher; Walters, Stephen; Bortolami, Oscar; Armitage, Fiona; Leonard, Robert; Gath, Jacqui; Revell, Deirdre; Green, Tracy; Wyld, Lynda

Authors

Karen Collins

Malcolm Reed

Kate Lifford

Maria Burton

Adrian Edwards

Alistair Ring

Katherine Brain

Helena Harder

Thompson Robinson

Kwok-Leung Cheung

Jenna Morgan

Riccardo Audisio

Susan Ward

Paul Richards

Charlene Martin

Tim Chater

Kirsty Pemberton

Anthony Nettleship

Christopher Murray

Stephen Walters

Oscar Bortolami

Fiona Armitage

Robert Leonard

Jacqui Gath

Deirdre Revell

Tracy Green

Lynda Wyld



Abstract

Introduction: While breast cancer outcomes are improving steadily in younger women due to advances in screening and improved therapies, there has been little change in outcomes among the older age group. It is inevitable that comorbidities/frailty rates are higher, which may increase the risks of some breast cancer treatments such as surgery and chemotherapy, many older women are healthy and may benefit from their use. Adjusting treatment regimens appropriately for age/comorbidity/frailty is variable and largely non-evidence based, specifically with regard to rates of surgery for operable oestrogen receptor-positive disease and rates of chemotherapy for high-risk disease.


Methods and analysis: This multicentre, parallel group, pragmatic cluster randomised controlled trial (RCT) (2015-18) reported here is nested within a larger ongoing ‘Age Gap Cohort Study’ (2012-18RP-PG-1209-10071), aims to evaluate the effectiveness of a complex intervention of decision support interventions to assist in the treatment decision making for early breast cancer in older women. The interventions include two patient decision aids (primary endocrine therapy vs surgery/antioestrogen therapy and chemotherapy vs no chemotherapy) and a clinical treatment outcomes algorithm for clinicians.


Ethics and dissemination: National and local ethics committee approval was obtained for all UK participating sites. Results from the trial will be submitted for publication in international peer-reviewed scientific journals.

Citation

Collins, K., Reed, M., Lifford, K., Burton, M., Edwards, A., Ring, A., …Wyld, L. (2017). Bridging the age gap in breast cancer: evaluation of decision support interventions for older women with operable breast cancer: protocol for a cluster randomised controlled trial. BMJ Open, 7(7), https://doi.org/10.1136/bmjopen-2016-015133

Journal Article Type Article
Acceptance Date May 19, 2017
Online Publication Date Jul 31, 2017
Publication Date Jul 1, 2017
Deposit Date Aug 23, 2017
Publicly Available Date Aug 23, 2017
Journal BMJ Open
Electronic ISSN 2044-6055
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 7
Issue 7
Article Number e015133
DOI https://doi.org/10.1136/bmjopen-2016-015133
Public URL http://eprints.nottingham.ac.uk/id/eprint/45105
Publisher URL http://bmjopen.bmj.com/content/7/7/e015133
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

Files


COLLINS Age Gap protocol BMJ.full July 2017.pdf (631 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





Downloadable Citations