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Biomarkers of stroke recovery: consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable

Boyd, Lara A.; Hayward, Kathryn S.; Ward, Nick S.; Stinear, Cathy M.; Rosso, Charlotte; Fisher, Rebecca J.; Carter, Alexandre R.; Leff, Alex P.; Copland, David A.; Carey, Leeanne M.; Cohen, Leonardo G.; Basso, D. Michele; Maguire, Jane M.; Cramer, Steven C.

Authors

Lara A. Boyd

Kathryn S. Hayward

Nick S. Ward

Cathy M. Stinear

Charlotte Rosso

Rebecca J. Fisher

Alexandre R. Carter

Alex P. Leff

David A. Copland

Leeanne M. Carey

Leonardo G. Cohen

D. Michele Basso

Jane M. Maguire

Steven C. Cramer



Abstract

The most difficult clinical questions in stroke rehabilitation are ‘‘What is this patient’s potential for recovery?’’ and ‘‘What is the best rehabilitation strategy for this person, given her/his clinical profile?’’ Without answers to these questions, clinicians struggle to make decisions regarding the content and focus of therapy, and researchers design studies that inadvertently mix participants who have a high likelihood of responding with those who do not. Developing and implementing biomarkers that distinguish patient subgroups will help address these issues and unravel the factors important to the recovery process. The goal of the present paper is to provide a consensus statement regarding the current state of the evidence for stroke recovery biomarkers. Biomarkers of motor, somatosensory, cognitive and language domains across the recovery timeline post-stroke are considered; with focus on brain structure and function, and exclusion of blood markers and genetics. We provide evidence for biomarkers that are considered ready to be included in clinical trials, as well as others that are promising but not ready and so represent a developmental priority. We conclude with an example that illustrates the utility of biomarkers in recovery and rehabilitation research, demonstrating how the inclusion of a biomarker may enhance future clinical trials. In this way, we propose a way forward for when and where we can include biomarkers to advance the efficacy of the practice of, and research into, rehabilitation and recovery after stroke.

Citation

Boyd, L. A., Hayward, K. S., Ward, N. S., Stinear, C. M., Rosso, C., Fisher, R. J., …Cramer, S. C. (2017). Biomarkers of stroke recovery: consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 12(5), https://doi.org/10.1177/1747493017714176

Journal Article Type Article
Acceptance Date May 15, 2017
Online Publication Date Jul 12, 2017
Publication Date Jul 1, 2017
Deposit Date Jul 21, 2017
Publicly Available Date Jul 21, 2017
Journal International Journal of Stroke
Print ISSN 1747-4930
Electronic ISSN 1747-4949
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 12
Issue 5
DOI https://doi.org/10.1177/1747493017714176
Keywords Biomarker, motor, somatosensory, cognition, language, stratification, function, clinical trial, neuroimaging, human
Public URL http://eprints.nottingham.ac.uk/id/eprint/44360
Publisher URL http://journals.sagepub.com/doi/full/10.1177/1747493017714176
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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