Ovarian reserve after salpingectomy: a systematic review and meta-analysis

Mohamed, Ahmed Aboelfadle; Yosef, Ali Haroun; James, Cathryn; Al-Hussaini, Tarek Khalaf; Bedaiwy, Mohamed Ali; Amer, Saad A.

Abstract

Introduction

Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve.
Material and methods

A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-Müllerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into RevMan software for calculation of the weighted mean difference (WMD) and 95% CI. Two groups of studies were analyzed separately: group 1 (six studies, n = 464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n = 169) vs. healthy controls (n = 154).
Results

Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, −0.10 ng/mL; 95% CI −0.19 to 0.00, I2 = 0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, −0.11 ng/mL; 95% CI −0.37 to 0.14, I2 = 77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants’ age (<40 years) still showed no statistically significant changes in circulating AMH.
Conclusion

Salpingectomy does not seem to compromise ovarian reserve in the short-term. However, the long-term effect of salpingectomy on ovarian reserve remains uncertain.

Citation

Mohamed, A. A., Yosef, A. H., James, C., Al-Hussaini, T. K., Bedaiwy, M. A., & Amer, S. A. (2017). Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica, 96(7), 795-803. https://doi.org/10.1111/aogs.13133

• Journal Article Type: Article
• Acceptance Date: Mar 11, 2017
• Online Publication Date: May 4, 2017
• Publication Date: Jun 20, 2017
• Deposit Date: Jul 17, 2017
• Publicly Available Date: Jul 17, 2017
• Journal: Acta Obstetricia et Gynecologica Scandinavica
• Print ISSN: 0001-6349
• Electronic ISSN: 1600-0412
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 96
• Issue: 7
• Pages: 795-803
• DOI: https://doi.org/10.1111/aogs.13133
• Keywords: Salpingectomy, Ovarian reserve, Anti-Müllerian hormone, Ovarian function, Laparoscopy
• Public URL: https://nottingham-repository.worktribe.com/output/867326
• Publisher URL: https://doi.org/10.1111/aogs.13133
• Additional Information: This is the peer reviewed version of the following article: Mohamed AA, Yosef AH, James C, Al-Hussaini TK, Bedaiwy MA, Amer SAKS. Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 2017; 96:795–803., which has been published in final form at https://doi.org/10.1111/aogs.13133. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• Contract Date: Jul 17, 2017