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Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay

Pezze, Marie A.; Marshall, Hayley J.; Fone, Kevin C.F.; Cassaday, Helen J.


Marie A. Pezze

Hayley J. Marshall

Professor of Neuroscience

Professor of Behavioural Neuroscience


Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesion studies cannot distinguish effects on encoding and retrieval. The interval between encoding and retrieval tests may also be a critical determinant of the role of the ACgx. The current series of experiments used micro-infusion of the GABAA receptor agonist, muscimol, into ACgx to reversibly inactivate the area and distinguish its role in encoding and retrieval. ACgx infusions of muscimol, before encoding did not alter NOR assessed after a delay of 20 min or 24 h. However, when infused into the ACgx before retrieval muscimol impaired NOR assessed after a delay of 24 h, but not after a 20 min retention test. Together these findings suggest that the ACgx plays a time-dependent role in the retrieval, but not the encoding, of NOR memory, neuronal activation being required for the retrieval of remote (24 h old), but not recent (20 min old) visual memory.


Pezze, M. A., Marshall, H. J., Fone, K. C., & Cassaday, H. J. (2017). Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay. Learning and Memory, 24(7), 310-317.

Journal Article Type Article
Acceptance Date Apr 21, 2017
Online Publication Date Jun 15, 2017
Publication Date 2017-07
Deposit Date May 4, 2017
Publicly Available Date Jun 15, 2017
Journal Learning & Memory
Print ISSN 1072-0502
Electronic ISSN 1549-5485
Publisher Cold Spring Harbor Laboratory Press
Peer Reviewed Peer Reviewed
Volume 24
Issue 7
Pages 310-317
Keywords novel object recognition; anterior cingulate cortex; muscimol; memory retrieval; GABAA receptor
Public URL
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Copyright Statement Copyright information regarding this work can be found at the following address:


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