Anna Rachelle Mislang
Controversial issues in the management of older adults with early breast cancer
Mislang, Anna Rachelle; Cheung, Kwok-Leung; Hamaker, Marije E.; Kunkler, Ian; Markopoulos, Christos; Orecchia, Roberto; Brain, Etienne; Biganzoli, Laura
Authors
Professor KWOK_LEUNG CHEUNG KWOK_LEUNG.CHEUNG@NOTTINGHAM.AC.UK
Deputy Head of Education & Director of The Bmbs Medicine Programmes
Marije E. Hamaker
Ian Kunkler
Christos Markopoulos
Roberto Orecchia
Etienne Brain
Laura Biganzoli
Abstract
It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in less fit older patients where a conservative approach is commonly perceived to be more appropriate. The optimal management of this population is unknown and treatment decision should be personalized. This review article will discuss several controversial issues in managing older adults with early breast cancer in a multidisciplinary setting, including the role of surgical treatment of the axilla in clinically node negative disease, radiotherapy after breast conservation surgery in low-risk tumours, personalizing adjuvant systemic therapy, and geriatric assessments in breast cancer treatment decisions.
Citation
Mislang, A. R., Cheung, K.-L., Hamaker, M. E., Kunkler, I., Markopoulos, C., Orecchia, R., …Biganzoli, L. (in press). Controversial issues in the management of older adults with early breast cancer. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2017.05.004
Journal Article Type | Article |
---|---|
Acceptance Date | May 24, 2017 |
Online Publication Date | Jun 9, 2017 |
Deposit Date | Aug 25, 2017 |
Publicly Available Date | Aug 25, 2017 |
Journal | Journal of Geriatric Oncology |
Print ISSN | 1879-4068 |
Electronic ISSN | 1879-4068 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1016/j.jgo.2017.05.004 |
Keywords | Older adults ; Early breast cancer ; Surgery ; Radiotherapy Chemotherapy ; Geriatric assessment |
Public URL | https://nottingham-repository.worktribe.com/output/864981 |
Publisher URL | http://www.sciencedirect.com/science/article/pii/S1879406817300978?via%3Dihub |
Contract Date | Aug 25, 2017 |
Files
MISLANG JGO-D-17-00003R1 Manuscript Revision Final.pdf
(162 Kb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
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