Canine idiopathic chronic hepatitis

Bexfield, Nicholas

Abstract

Canine idiopathic hepatitis is a common disease, categorized histologically by presence of hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis.

Clinical signs are vague and non-specific, but there are known breed, age and gender predispositions.

Results of clinical pathology are non-specific, but usually include elevations in liver enzymes and function impairment; a liver biopsy is required for diagnosis.

Management involves around the use of an anti-inflammatory dose of glucocorticoids and other supportive and symptomatic therapies including ursodeoxycholic acid, antioxidants, diuretics, and diet.

The prognosis is variable, but there are known prognostic indicators, especially the presence of portal hypertension

Citation

Bexfield, N. (2017). Canine idiopathic chronic hepatitis. Veterinary Clinics of North America: Small Animal Practice, 47(3), https://doi.org/10.1016/j.cvsm.2016.11.012

• Journal Article Type: Article
• Acceptance Date: Jan 4, 2017
• Online Publication Date: Jan 4, 2017
• Publication Date: May 31, 2017
• Deposit Date: Feb 28, 2017
• Publicly Available Date: Feb 28, 2017
• Journal: Veterinary Clinics of North America: Small Animal Practice
• Print ISSN: 0195-5616
• Electronic ISSN: 1878-1306
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 47
• Issue: 3
• DOI: https://doi.org/10.1016/j.cvsm.2016.11.012
• Keywords: Idiopathic; Hepatitis; Canine; Diagnosis; Management; Prognosis
• Public URL: https://nottingham-repository.worktribe.com/output/863658
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0195561616301589