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Canine idiopathic chronic hepatitis

Bexfield, Nicholas


Nicholas Bexfield


Canine idiopathic hepatitis is a common disease, categorized histologically by presence of hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis.

Clinical signs are vague and non-specific, but there are known breed, age and gender predispositions.

Results of clinical pathology are non-specific, but usually include elevations in liver enzymes and function impairment; a liver biopsy is required for diagnosis.

Management involves around the use of an anti-inflammatory dose of glucocorticoids and other supportive and symptomatic therapies including ursodeoxycholic acid, antioxidants, diuretics, and diet.

The prognosis is variable, but there are known prognostic indicators, especially the presence of portal hypertension


Bexfield, N. (2017). Canine idiopathic chronic hepatitis. Veterinary Clinics of North America: Small Animal Practice, 47(3),

Journal Article Type Article
Acceptance Date Jan 4, 2017
Online Publication Date Jan 4, 2017
Publication Date May 31, 2017
Deposit Date Feb 28, 2017
Publicly Available Date Feb 28, 2017
Journal Veterinary Clinics of North America: Small Animal Practice
Print ISSN 0195-5616
Electronic ISSN 1878-1306
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 47
Issue 3
Keywords Idiopathic; Hepatitis; Canine; Diagnosis; Management; Prognosis
Public URL
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