Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae)

Lucky, Legbosi; Yibali, Oboma; Ekramy, Elmorsy; Wayne, Carter

Abstract

Background

Glyphae brevis leaf is reported in ethnomedicine as a treatment for hepatitis and jaundice; however, no studies have hitherto investigated the mechanistic basis of these claims.
Methods

A hepato-protective role of G. brevis hydromethanolic (GBH) leaf extract was established against carbon tetrachloride (CCl4)-induced hepatotoxicity. Twenty-four hours after a CCl4 challenge, rats were sacrificed and serum hematological indices, lipid profile, and biochemical parameters were determined. The antioxidant enzymes parameters (glutathione, catalase, and superoxide dismutase) and lipid peroxidation product (thiobarbituric reactive substances) levels in liver homogenates were evaluated. Changes in the liver cyto-architecture of different treatment groups were also investigated.
Results

The GBH extract produced no significant impact on weight and hematological indices. Intoxication with CCl4 significantly (p

Citation

Lucky, L., Yibali, O., Ekramy, E., & Wayne, C. (2018). Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae). Journal of Basic and Clinical Physiology and Pharmacology, 29(6), 609-619. https://doi.org/10.1515/jbcpp-2017-0058

• Journal Article Type: Article
• Acceptance Date: Apr 28, 2018
• Online Publication Date: Aug 29, 2018
• Publication Date: Aug 29, 2018
• Deposit Date: Jul 31, 2018
• Publicly Available Date: Aug 30, 2019
• Print ISSN: 0334-1534
• Electronic ISSN: 2191-0286
• Publisher: De Gruyter
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 6
• Pages: 609-619
• DOI: https://doi.org/10.1515/jbcpp-2017-0058
• Keywords: Glyphaea brevis leaf; hepato-protection; hepatotoxicity; lipid profile; oxidative stress
• Public URL: https://nottingham-repository.worktribe.com/output/862553
• Publisher URL: https://www.degruyter.com/view/journals/jbcpp/29/6/article-p609.xml