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Screening for hepatocellular carcinoma: patient selection and perspectives

Fateen, Waleed; Ryder, Stephen

Authors

Waleed Fateen

Stephen Ryder



Abstract

Hepatocellular carcinoma (HCC) develops on the background of liver cirrhosis often from multiple, simultaneous factors. The diagnosis of a single small HCC comes with good prognosis and provides a potential for cure. In contrast, the diagnosis of multifocal, large HCC has high mortality and poor prognosis. Unfortunately, the majority of HCC is diagnosed at such late stages. A surveillance program endorsed by regional liver societies involves six-monthly ultrasound surveillance of at-risk patients. This had been in action for the last two decades. It has led to marked increase in the proportion of patients presenting with small unifocal nodules found on surveillance. The development of tools to enhance our ability in optimizing available surveillance is likely to improve the prognosis of patients with HCC. In this review, we discuss the difficulties in utilizing HCC surveillance and possible means of improvement.

Citation

Fateen, W., & Ryder, S. (2017). Screening for hepatocellular carcinoma: patient selection and perspectives. Journal of Hepatocellular Carcinoma, 2017(4), https://doi.org/10.2147/JHC.S105777

Journal Article Type Article
Acceptance Date Jan 17, 2017
Publication Date May 17, 2017
Deposit Date Feb 19, 2018
Publicly Available Date Feb 19, 2018
Journal Journal of Hepatocellular Carcinoma
Electronic ISSN 2253-5969
Publisher Dove Medical Press
Peer Reviewed Peer Reviewed
Volume 2017
Issue 4
DOI https://doi.org/10.2147/JHC.S105777
Keywords hepatocellular carcinoma, surveillance, screening, risk stratification
Public URL http://eprints.nottingham.ac.uk/id/eprint/49864
Publisher URL https://doi.org/10.2147/JHC.S105777
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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