Metal Resistance and Its Association With Antibiotic Resistance

Pal, Chandan; Asiani, Karishma R.; Arya, Sankalp; Rensing, Christopher; Stekel, Dov J.; Larsson, D.G. Joakim; Hobman, Jon L.

Abstract

Antibiotic resistance is recognised as a major global threat to public health by the World Health Organization. Currently, several hundred thousand deaths yearly can be attributed to infections with antibiotic-resistant bacteria. The major driver for the development of antibiotic resistance is considered to be the use, misuse and overuse of antibiotics in humans and animals. Nonantibiotic compounds, such as antibacterial biocides and metals, may also contribute to the promotion of antibiotic resistance through co-selection. This may occur when resistance genes to both antibiotics and metals/biocides are co-located together in the same cell (co-resistance), or a single resistance mechanism (e.g. an efflux pump) confers resistance to both antibiotics and biocides/metals (cross-resistance), leading to co-selection of bacterial strains, or mobile genetic elements that they carry. Here, we review antimicrobial metal resistance in the context of the antibiotic resistance problem, discuss co-selection, and highlight critical knowledge gaps in our understanding.

Citation

Pal, C., Asiani, K. R., Arya, S., Rensing, C., Stekel, D. J., Larsson, D. J., & Hobman, J. L. (2017). Metal Resistance and Its Association With Antibiotic Resistance. In R. K. Poole (Ed.), Microbiology of metal ions (261-313). Academic Press. https://doi.org/10.1016/bs.ampbs.2017.02.001

• Acceptance Date: Feb 14, 2017
• Online Publication Date: Apr 3, 2017
• Publication Date: Apr 3, 2017
• Deposit Date: May 31, 2017
• Peer Reviewed: Peer Reviewed
• Volume: 70
• Pages: 261-313
• Series Title: Advances in Microbial Physiology
• Book Title: Microbiology of metal ions
• ISBN: 9780128123867
• DOI: https://doi.org/10.1016/bs.ampbs.2017.02.001
• Keywords: Antibiotic resistance; Metal ion resistance; Co-selection; Co-resistance; Cross-resistance; Mercury; Copper; Silver; Arsenic; Zinc
• Public URL: https://nottingham-repository.worktribe.com/output/860922
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0065291117300085