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Metal Resistance and Its Association With Antibiotic Resistance

Pal, Chandan; Asiani, Karishma R.; Arya, Sankalp; Rensing, Christopher; Stekel, Dov J.; Larsson, D.G. Joakim; Hobman, Jon L.


Chandan Pal

Karishma R. Asiani

Sankalp Arya

Christopher Rensing

Professor of Computational Biology

D.G. Joakim Larsson

Associate Professor


Robert K. Poole


Antibiotic resistance is recognised as a major global threat to public health by the World Health Organization. Currently, several hundred thousand deaths yearly can be attributed to infections with antibiotic-resistant bacteria. The major driver for the development of antibiotic resistance is considered to be the use, misuse and overuse of antibiotics in humans and animals. Nonantibiotic compounds, such as antibacterial biocides and metals, may also contribute to the promotion of antibiotic resistance through co-selection. This may occur when resistance genes to both antibiotics and metals/biocides are co-located together in the same cell (co-resistance), or a single resistance mechanism (e.g. an efflux pump) confers resistance to both antibiotics and biocides/metals (cross-resistance), leading to co-selection of bacterial strains, or mobile genetic elements that they carry. Here, we review antimicrobial metal resistance in the context of the antibiotic resistance problem, discuss co-selection, and highlight critical knowledge gaps in our understanding.


Pal, C., Asiani, K. R., Arya, S., Rensing, C., Stekel, D. J., Larsson, D. J., & Hobman, J. L. (2017). Metal Resistance and Its Association With Antibiotic Resistance. In R. K. Poole (Ed.), Microbiology of metal ions (261-313). Academic Press.

Acceptance Date Feb 14, 2017
Online Publication Date Apr 3, 2017
Publication Date Apr 3, 2017
Deposit Date May 31, 2017
Peer Reviewed Peer Reviewed
Volume 70
Pages 261-313
Series Title Advances in Microbial Physiology
Book Title Microbiology of metal ions
ISBN 9780128123867
Keywords Antibiotic resistance; Metal ion resistance; Co-selection; Co-resistance; Cross-resistance; Mercury; Copper; Silver; Arsenic; Zinc
Public URL
Publisher URL
Contract Date May 26, 2017

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